Mechanism of Increased Renin Release in the Adrenalectomized Rat: Adrenal Insufficiency and Renin

We have previously suggested that inhibition of renin release by sodium chloride is related to absorptive chloride transport in the loop of Henle. Infusion of sodium chloride fails to inhibit renin release in the adrenalectomized (Adx) rat, and dexamethasone restores renin responsive-ness to sodium...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 1983-03, Vol.5 (2 Suppl I), p.I-47-I-52
Hauptverfasser:	WELCH, WILLIAM J, OTT, COBERN E, GUTHRIE, GORDON P, KOTCHEN, THEODORE A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenalectomy Animals Arginine Vasopressin - analogs & derivatives Arginine Vasopressin - pharmacology Dexamethasone - pharmacology Glomerular Filtration Rate - drug effects Hypotonic Solutions Kidney Concentrating Ability - drug effects Kidney Tubules - physiology Loop of Henle - physiology Male Osmolar Concentration Rats Renin - blood Sodium Chloride - pharmacology Urine Water Deprivation
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Zusammenfassung:	We have previously suggested that inhibition of renin release by sodium chloride is related to absorptive chloride transport in the loop of Henle. Infusion of sodium chloride fails to inhibit renin release in the adrenalectomized (Adx) rat, and dexamethasone restores renin responsive-ness to sodium chloride. The purpose of the present study was to evaluate the relationship between loop function (urinary diluting and concentration capacity) and plasma renin concentration (PRC) in the Adx rat. After hypotonic sodium chloride infusion, free water clearance (CH2OH^,) of Adx rats (0.56 ml/hr/100 g ± 0.17 SE) was decreased (p
ISSN:	0194-911X 1524-4563
DOI:	10.1161/01.HYP.5.2_Pt_2.I47