The primary B cell response to the O/core region of bacterial lipopolysaccharide is restricted to the Ly-1 lineage

Experiments were performed to test the hypothesis that Ly-1 B cells respond to antigenic challenge with LPS from gram-negative bacteria. To perform these experiments, the splenic fragment culture system for the study of B cell precursors was used. We found that a significant number of anti-O/core, b...

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