Protein Engineering

Protein Engineering

The prospects for protein engineering, including the roles of x-ray crystallography, chemical synthesis of DNA, and computer modeling of protein structure and folding, are discussed. It is now possible to attempt to modify many different properties of proteins by combining information on crystal str...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1983-02, Vol.219 (4585), p.666-671
1. Verfasser: Ulmer, Kevin M.
Format: Artikel
Sprache:eng
Schlagworte:
Amino acids
Base Sequence
chemical modification
computer applications
Crystal structure
Crystallography
Crystals
DNA
engineering
Enzyme substrates
Enzymes
Genes
Genetic Engineering
Models, Molecular
Molecular Biology - trends
Molecular structure
Mutagenesis
Property repairs
Protein Conformation
Protein engineering
Protein research
proteins
Proteins - genetics
reviews
X-ray crystallography
X-Ray Diffraction
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Beschreibung
Zusammenfassung:The prospects for protein engineering, including the roles of x-ray crystallography, chemical synthesis of DNA, and computer modeling of protein structure and folding, are discussed. It is now possible to attempt to modify many different properties of proteins by combining information on crystal structure and protein chemistry with artificial gene synthesis. Such techniques offer the potential for altering protein structure and function in ways not possible by any other method.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.6572017