Changes in water solubility of proteins in aging rat brain

Changes in the water solubility of proteins in the brain tissue of Wistar rats were investigated: ( i) during aging (in 3–32 month animals) and ( ii) 24 h after killing 3 month animals. The protein concentration was determined by the method of Lowry. In both cases we observed a considerable differen...

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Veröffentlicht in:	Archives of gerontology and geriatrics 1991, Vol.12 (1), p.41-48
Hauptverfasser:	KRISTOFIKOVA, Z, BENESOVA, O, TEJKALOVA, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Age-related changes Biological and medical sciences Cross-links Development. Metamorphosis. Moult. Ageing Fundamental and applied biological sciences. Psychology Postmortem changes Protein solubility Rat brain Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Zusammenfassung:	Changes in the water solubility of proteins in the brain tissue of Wistar rats were investigated: ( i) during aging (in 3–32 month animals) and ( ii) 24 h after killing 3 month animals. The protein concentration was determined by the method of Lowry. In both cases we observed a considerable difference in the protein solubility, i.e., that the ratio of water-soluble to water-insoluble proteins changed. A change of protein solubility was largest in the brain regions especially sensitive to the oxygen supply (hippocampus, striatum, hypothalamus and cortex) and is statistically significant already in 14 month animals.
ISSN:	0167-4943 1872-6976
DOI:	10.1016/0167-4943(91)90006-C