Effect of transfer of human ApoA1 gene on development of dyslipoproteinemias in rats: Age peculiarities

Effect of transfer of human ApoA1 gene on development of dyslipoproteinemias in rats: Age peculiarities

Transfer of human ApoA1 gene within the molecular construction which provides its expression, to the liver of the adult and aged rats resulted in the appearance of human protein in their blood, and was accompanied by changes in the content of high-density lipoproteins and of their subclasses HDL 3 a...

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Veröffentlicht in:Archives of gerontology and geriatrics 1991-11, Vol.13 (3), p.225-235
Hauptverfasser: Frolkis, V.V., Kordjum, V.A., Bogatskaya, L.N., Novikova, S.N., Shulzhenko, V.N., Kostetsky, I.E., Mozzhukhina, T.G., Potapenko, R.I., Sabko, V.E., Paramonova, G.I., Shkapenko, A.L.
Format: Artikel
Sprache:eng
Schlagworte:
Aging
Apolipoproteins
Gene implantation
Lipoproteins
Liver
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Zusammenfassung:Transfer of human ApoA1 gene within the molecular construction which provides its expression, to the liver of the adult and aged rats resulted in the appearance of human protein in their blood, and was accompanied by changes in the content of high-density lipoproteins and of their subclasses HDL 3 and HDL 2, as well as by the shifts in their protein and lipid composition. Synthesis of human ApoA1 was more marked in the organism of adult rats, and gene-regulatory shifts in aged rats.
ISSN:0167-4943
1872-6976
DOI:10.1016/0167-4943(91)90044-Q