Therapy of malignant APUD cell tumors: Effectiveness of DTIC
Eleven patients with malignant APUD tumors, five islet cell carcinomas, five carcinoid tumors and one medullary carcinoma of the thyroid were treated with DTIC. Nine of 11 patients benefitted from treatment. A literature review revealed that other APUD tumors responded when treated with DTIC. DTIC i...
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Veröffentlicht in: | Cancer 1983-03, Vol.51 (5), p.790-794 |
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creator | Kessinger, Anne Foley, John F. Lemon, Henry M. |
description | Eleven patients with malignant APUD tumors, five islet cell carcinomas, five carcinoid tumors and one medullary carcinoma of the thyroid were treated with DTIC. Nine of 11 patients benefitted from treatment. A literature review revealed that other APUD tumors responded when treated with DTIC. DTIC is a useful agent for treatment of malignant APUDomas, and may be the drug of choice for islet cell carcinoma of the pancreas. |
doi_str_mv | 10.1002/1097-0142(19830301)51:5<790::AID-CNCR2820510507>3.0.CO;2-3 |
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Nine of 11 patients benefitted from treatment. A literature review revealed that other APUD tumors responded when treated with DTIC. DTIC is a useful agent for treatment of malignant APUDomas, and may be the drug of choice for islet cell carcinoma of the pancreas.</description><subject>Adenoma, Islet Cell - drug therapy</subject><subject>Adult</subject><subject>Aged</subject><subject>Apudoma - drug therapy</subject><subject>Carcinoid Tumor - drug therapy</subject><subject>Carcinoma - drug therapy</subject><subject>Dacarbazine - therapeutic use</subject><subject>Female</subject><subject>Humans</subject><subject>Ileal Neoplasms - drug therapy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Metastasis</subject><subject>Pancreatic Neoplasms - drug therapy</subject><subject>Thyroid Neoplasms - drug therapy</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkN1Kw0AQhRdRaq0-gpAr0YvU2d3sT2oRalq1UKxIC-LNkKQbjSRNzbZK396EVkEvBGFhWM6ZMzMfIVcU2hSAnVPwlQvUY6fU1xw40DNBO6KrfOh0esO-G9wFD0wzEBQEqEvehnYwvmAu3yHN7-Zd0gQA7QqPP-6TA2tfq69igjdIQzJfSOo1SXfyYspwsXaKxMnDLH2eh_Ol07uf9p3YZJmzXOVFaTvOIElMvEzfzdxYW5v7k2FwSPaSMLPmaFtbZHo9mAS37mh8Mwx6Izf2pFTuTEhFgSsdzwz4SQSMSRrFEiDRUgtNmSe90PDIj3wT-lRwoSTEsYiYMDpRvEVONrmLsnhbGbvEPLX1euHcFCuLGnh1jYDK-LQxxmVhbWkSXJRpHpZrpIA1WqzpYE0Hv9CiqB5WaBErtPgTLXIEDMbIkFfhx9stVlFuZt_RW5aVbjb6R5qZ9b8m_zn4l8I_Ad0bkuc</recordid><startdate>19830301</startdate><enddate>19830301</enddate><creator>Kessinger, Anne</creator><creator>Foley, John F.</creator><creator>Lemon, Henry M.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19830301</creationdate><title>Therapy of malignant APUD cell tumors: Effectiveness of DTIC</title><author>Kessinger, Anne ; Foley, John F. ; Lemon, Henry M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4667-d56710378cde09fb02261bc600f8685812464ae3b9b9ea91535760cc5b25e8f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Adenoma, Islet Cell - drug therapy</topic><topic>Adult</topic><topic>Aged</topic><topic>Apudoma - drug therapy</topic><topic>Carcinoid Tumor - drug therapy</topic><topic>Carcinoma - drug therapy</topic><topic>Dacarbazine - therapeutic use</topic><topic>Female</topic><topic>Humans</topic><topic>Ileal Neoplasms - drug therapy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Metastasis</topic><topic>Pancreatic Neoplasms - drug therapy</topic><topic>Thyroid Neoplasms - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kessinger, Anne</creatorcontrib><creatorcontrib>Foley, John F.</creatorcontrib><creatorcontrib>Lemon, Henry M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kessinger, Anne</au><au>Foley, John F.</au><au>Lemon, Henry M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Therapy of malignant APUD cell tumors: Effectiveness of DTIC</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>1983-03-01</date><risdate>1983</risdate><volume>51</volume><issue>5</issue><spage>790</spage><epage>794</epage><pages>790-794</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><abstract>Eleven patients with malignant APUD tumors, five islet cell carcinomas, five carcinoid tumors and one medullary carcinoma of the thyroid were treated with DTIC. Nine of 11 patients benefitted from treatment. A literature review revealed that other APUD tumors responded when treated with DTIC. DTIC is a useful agent for treatment of malignant APUDomas, and may be the drug of choice for islet cell carcinoma of the pancreas.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>6295614</pmid><doi>10.1002/1097-0142(19830301)51:5<790::AID-CNCR2820510507>3.0.CO;2-3</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adenoma, Islet Cell - drug therapy Adult Aged Apudoma - drug therapy Carcinoid Tumor - drug therapy Carcinoma - drug therapy Dacarbazine - therapeutic use Female Humans Ileal Neoplasms - drug therapy Male Middle Aged Neoplasm Metastasis Pancreatic Neoplasms - drug therapy Thyroid Neoplasms - drug therapy |
title | Therapy of malignant APUD cell tumors: Effectiveness of DTIC |
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