Therapy of malignant APUD cell tumors: Effectiveness of DTIC

Eleven patients with malignant APUD tumors, five islet cell carcinomas, five carcinoid tumors and one medullary carcinoma of the thyroid were treated with DTIC. Nine of 11 patients benefitted from treatment. A literature review revealed that other APUD tumors responded when treated with DTIC. DTIC i...

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Veröffentlicht in:	Cancer 1983-03, Vol.51 (5), p.790-794
Hauptverfasser:	Kessinger, Anne, Foley, John F., Lemon, Henry M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoma, Islet Cell - drug therapy Adult Aged Apudoma - drug therapy Carcinoid Tumor - drug therapy Carcinoma - drug therapy Dacarbazine - therapeutic use Female Humans Ileal Neoplasms - drug therapy Male Middle Aged Neoplasm Metastasis Pancreatic Neoplasms - drug therapy Thyroid Neoplasms - drug therapy
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Beschreibung
Zusammenfassung:	Eleven patients with malignant APUD tumors, five islet cell carcinomas, five carcinoid tumors and one medullary carcinoma of the thyroid were treated with DTIC. Nine of 11 patients benefitted from treatment. A literature review revealed that other APUD tumors responded when treated with DTIC. DTIC is a useful agent for treatment of malignant APUDomas, and may be the drug of choice for islet cell carcinoma of the pancreas.
ISSN:	0008-543X 1097-0142
DOI:	10.1002/1097-0142(19830301)51:5<790::AID-CNCR2820510507>3.0.CO;2-3