Baroreflex Response and Vasodilating Drugs in Essential Hypertension

Blood pressure, heart rate, and arterial diameter of the brachial artery were studied in patients with sustained essential hypertension before and after administration of three vasodilating drugs: dihydralazine, diltiazem, and dinitrate isosorbide (ISDN). The diameter of the brachial artery was meas...

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Veröffentlicht in:	Chest 1983-02, Vol.83 (2), p.325-327
Hauptverfasser:	Levenson, J.A., Safar, M.E., Bouthier, J.E., Benetos, A.M., Simon, A. Ch
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Benzazepines - therapeutic use Blood Pressure - drug effects Brachial Artery - drug effects Dihydralazine - therapeutic use Diltiazem - therapeutic use Heart Rate - drug effects Humans Hydralazine - analogs & derivatives Hypertension - drug therapy Isosorbide Dinitrate - therapeutic use Male Middle Aged Pressoreceptors - drug effects Reflex - drug effects Vascular Resistance - drug effects
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Zusammenfassung:	Blood pressure, heart rate, and arterial diameter of the brachial artery were studied in patients with sustained essential hypertension before and after administration of three vasodilating drugs: dihydralazine, diltiazem, and dinitrate isosorbide (ISDN). The diameter of the brachial artery was measured using a pulsed Doppler device, enabling the angle between the ultrasound beam and the vessel axis to be evaluated with a precision inferior to 2 percent. The three drugs had similar effects in decreasing the blood pressure and the forearm vascular resistance. Dihydralazine reduced the arterial diameter (p
ISSN:	0012-3692 1931-3543
DOI:	10.1378/chest.83.2_Supplement.325