Epidemiology of multiple sclerosis in Arabs in Kuwait: A comparative study between Kuwaitis and Palestinians

On December 31, 1988 there were 201 registered multiple sclerosis patients in Kuwait, an overall prevalence rate (PR) of 10.2 per 100000; among them were 186 Arabs, of whom 72 were Palestinians and 51 Kuwaitis. Comparison of these two subgroups, who had a similar age distribution revealed that the d...

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Veröffentlicht in:	Journal of the neurological sciences 1990-12, Vol.100 (1), p.137-141
Hauptverfasser:	Al-Din, A.S. Najim, Khogali, M., Poser, C.M., Al-Nassar, K.E., Shakir, R., Hussain, J., Behbahani, K., Chadha, G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Arabs Biological and medical sciences Blood Group Antigens - genetics Comparative study Cross-Sectional Studies Emigration and Immigration Epidemiology Ethnic Groups Europe - ethnology Eye Color - genetics Female Genetic Predisposition to Disease HLA-D Antigens - genetics Humans Israel - ethnology Kuwait - epidemiology Male Medical sciences Middle Aged Middle East - ethnology Multiple sclerosis Multiple Sclerosis - epidemiology Multiple Sclerosis - ethnology Multiple Sclerosis - genetics Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Neurology
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Zusammenfassung:	On December 31, 1988 there were 201 registered multiple sclerosis patients in Kuwait, an overall prevalence rate (PR) of 10.2 per 100000; among them were 186 Arabs, of whom 72 were Palestinians and 51 Kuwaitis. Comparison of these two subgroups, who had a similar age distribution revealed that the disease was2 1/2 times more frequent among Palestinians (PR 23.8/100 000) than among Kuwaitis (PR 9.5/100 000). Palestinians also showed significant differences from Kuwaitis in eye color, blood group distribution and HLA-DR and HLA-DQW epitopes frequency. This suggests that genetic rather than environmental factors might be the underlying cause for the high susceptibility to develop MS among Arabs originating from the Eastern Mediterranean basin.
ISSN:	0022-510X 1878-5883
DOI:	10.1016/0022-510X(90)90024-H