A Clinical Evaluation of an S 30 Dentifrice on Periodontal Disease using the Double Blind Method

The clinical effect of an S 30 dentifrice, containing a hypertonic salt, on simple gingivitis and marginal periodontitis was examined, using the double blind method, with an inactive placebo as the control. The S 30 dentifrice contains 30% sodium chloride, 0.05% isopropyl methylphenol, 0.01% thymol and 0.1% clove oil in a toothpaste base. Using the Scrubbing or Bass method, tooth brushing was performed by all the patients three times a day for 4 weeks. The clinical effect of the S 30 dentifrice was assessed using the Mann-Whitney U-test based on the reduction ratio of the total scores of the indices to 4 clinical assessments (gingival redness, swelling, bleeding and pus-discharge) and the total number of the clinical conditions to 9 clinical assessments (plaque, calculus, redness, swelling, pocket depth, bleeding, pus-discharge, mobility and halitosis) respectively in an initial examination before using the S30 dentifrice was initiated and at the end of every weeks thereafter for the entire 4 weeks of the evaluation. The results were as follows: 1. Simple gingivitis showed a statistically significant difference (P