Biotransformation and pharmacokinetics of AWD 26-06, 8-chloro- 5,10-dihydro-5-[bis(2-hydroxyethyl)aminoacetyl-11H-dibenzo[b,c[1,4diazepin-11-one hydrochloride, in the rat

Biotransformation and pharmacokinetics of AWD 26-06, 8-chloro- 5,10-dihydro-5-[bis(2-hydroxyethyl)aminoacetyl-11H-dibenzo[b,c[1,4diazepin-11-one hydrochloride, in the rat

Following p.o. and i.v. application of the 14C-labelled AWD 26-06 (6 mg/kg b.w.) with anticholinergic activity, blood levels (-24 h) and excretion (urine, feces-72 h; bile-7 h) were studied in Wistar rats. Intestinal absorption amounted to 30% of the dose administered in water solution. Elimination...

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Veröffentlicht in:Pharmazie 1990-07, Vol.45 (8), p.607-609
Hauptverfasser: Klemm, W, Morgenroth, U, Zerjatke, W, Joram, U, Gedan, A, Pfeifer, S
Format: Artikel
Sprache:ger
Schlagworte:
Animals
Biotransformation
Dibenzazepines - metabolism
Dibenzazepines - pharmacokinetics
Dibenzazepines - urine
Feces - chemistry
Male
Rats
Rats, Inbred Strains
Spectrophotometry, Ultraviolet
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Zusammenfassung:Following p.o. and i.v. application of the 14C-labelled AWD 26-06 (6 mg/kg b.w.) with anticholinergic activity, blood levels (-24 h) and excretion (urine, feces-72 h; bile-7 h) were studied in Wistar rats. Intestinal absorption amounted to 30% of the dose administered in water solution. Elimination half-lives in blood were 0.6 h and (after Cmax 3-4 h p.a.) 8 h. Excretion was mainly by feces (unchanged drug and biliary excreted metabolites) and to less extent by urine.
ISSN:0031-7144