Use of the 82Sr/ 82Rb Generator in Clinical PET Studies

The use of the 82Sr/ 82Rb generator in clinical positron emission tomography (PET) studies of myocardial perfusion has been described. An infusion pump is used to deliver the short-lived 82Rb from the generator to the patient. Various characteristics of the generator and the infusion system are desc...

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Veröffentlicht in:	International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology Nuclear medicine and biology, 1990, Vol.17 (8), p.763,767-765,768
Hauptverfasser:	Saha, Gopal B., Go, Raymundo T., Macintyre, William J., Marwick, Thomas H., Beachler, Annette, King, Janet L., Neumann, Donald R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Coronary Circulation Coronary Disease - diagnostic imaging Coronary Disease - physiopathology Humans Infusion Pumps Investigative techniques, diagnostic techniques (general aspects) Medical sciences Miscellaneous. Technology Radionuclide Generators Radionuclide investigations Rubidium Radioisotopes - administration & dosage Tomography, Emission-Computed
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Zusammenfassung:	The use of the 82Sr/ 82Rb generator in clinical positron emission tomography (PET) studies of myocardial perfusion has been described. An infusion pump is used to deliver the short-lived 82Rb from the generator to the patient. Various characteristics of the generator and the infusion system are described. The 82Rb yield was 69.8 ± 13.3% and the 82Sr breakthrough was always less than the limit of 0.02 μCi/mCi 82Rb. The yield of 82Rb increased with the flow rate and the potency of the generator. Patients with coronary artery disease were studied for myocardial perfusion abnormalities by the 82Rb PET technique and images of excellent diagnostic quality were obtained.
ISSN:	0883-2897
DOI:	10.1016/0883-2897(90)90023-T