Effects of vanadate on heart protein kinase

Effects of vanadate on heart protein kinase

The effects of vanadate on the protein kinase activity in the rat heart were investigated. Vanadate produced a marked increase of protein kinase activity and of cyclic AMP and cyclic GMP levels in rat heart strips. Vanadate also increased the activity of both the holoenzyme and the catalytic subunit...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Biochemical medicine 1982-12, Vol.28 (3), p.353-357
Hauptverfasser: Catalan, R.E., Martinez, A.M., Aragones, M.D., Godoy, J.E., Robles, A., Miguel, B.G.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cyclic AMP - metabolism
Cyclic GMP - metabolism
Male
Myocardium - enzymology
Protein Kinases - metabolism
Rats
Rats, Inbred Strains
Vanadates
Vanadium - pharmacology
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The effects of vanadate on the protein kinase activity in the rat heart were investigated. Vanadate produced a marked increase of protein kinase activity and of cyclic AMP and cyclic GMP levels in rat heart strips. Vanadate also increased the activity of both the holoenzyme and the catalytic subunit from beef heart in in vitro experiments. These results indicate that vanadate affects the protein kinase activity of the heart (a phenomenon probably related to its inotropic effect); the same results and more data in support of a general regulatory role for vanadate.
ISSN:0006-2944
1557-7996
DOI:10.1016/0006-2944(82)90090-4