Current psychopharmacogenetic strategies in primary affective disorders

Abstract 1. The evidence is substantial that primary affective disorders are genetically inherited. 2. Using pharmacological probes or strategies, biological markers of the gene(s) should be able to be ascertained or induced during remission of illness. 3. Genetic marker criteria are defined and are...

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Veröffentlicht in:	Progress in neuro-psychopharmacology & biological psychiatry 1982, Vol.6 (4), p.675-679
Hauptverfasser:	Waters, Brent G., Lapierre, Yvon D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bipolar Disorder - genetics Bipolar Disorder - metabolism Brain - metabolism Chromosome Mapping criteria Depressive Disorder - genetics Depressive Disorder - metabolism genetic inheritance Genetic Markers Humans markers Neurotransmitter Agents - metabolism pharmacologic probes primary affective disorder Receptors, Neurotransmitter - metabolism
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Zusammenfassung:	Abstract 1. The evidence is substantial that primary affective disorders are genetically inherited. 2. Using pharmacological probes or strategies, biological markers of the gene(s) should be able to be ascertained or induced during remission of illness. 3. Genetic marker criteria are defined and are applied to the scanty existing data. 4. It is concluded that these strategies have yet to yield a clear marker of primary affective disorder.
ISSN:	0278-5846 1878-4216
DOI:	10.1016/S0278-5846(82)80168-1