Monosomy 20: A nonrandom finding in childhood acute lymphoblastic leukemia

We describe four cases of childhood acute lymphoblastic leukemia with monosomy 20 as the sole cytogenetic abnormality. These cases represent 3.4% of cytogenetically abnormal childhood ALL studied in our institute at diagnosis. The patients presented at similar age, ranging from 31 to 36 months. All...

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Veröffentlicht in:	Genes chromosomes & cancer 1990-09, Vol.2 (3), p.182-185
Hauptverfasser:	Betts, David R., Kingston, Judith E., Dorey, Elaine L., Young, Bryan D., Webb, David, Katz, Fay E., Gibbons, Barbara
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD - analysis Bone Marrow - pathology Cells, Cultured Child, Preschool chromosome 20 Chromosomes, Human, Pair 20 Female HLA-DR Antigens - analysis Humans Karyotyping Male Metaphase Monosomy Phenotype Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - immunology Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology
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Zusammenfassung:	We describe four cases of childhood acute lymphoblastic leukemia with monosomy 20 as the sole cytogenetic abnormality. These cases represent 3.4% of cytogenetically abnormal childhood ALL studied in our institute at diagnosis. The patients presented at similar age, ranging from 31 to 36 months. All four patients remain in first remission with survival time being at least 20 months from the time of diagnosis.
ISSN:	1045-2257 1098-2264
DOI:	10.1002/gcc.2870020303