Acute myelogenous leukemia in a child with primary involvement of chromosomes 11 and X

The chromosomes of a case of acute myelogenous leukemia in an infant of 7 months were analyzed by means of high resolution banding achieved without mitotic synchronization. All cells of both samples contained 2 deviating chromosomes resulting from rearrangements of X at q22 and of 11 at p13, p15 and q23. Twenty-seven per cent of the cells of the first sample and 51% of the second sample in addition had an inverted (mirror) duplication of the "variable" region of the long arm of chromosome 1 (1q12). At the second fixation this cell clone had undergone further evolution leading to one clone with trisomy for the distal half of the short arm of chromosome 6 (6p21.2 arrow right pter) and another clone with rcp t(7; 12) (q13; q15).