Protecting Groups for the Enzymatic Peptide Synthesis
In chemical peptide synthesis, various protecting groups have been optimized for application in organic media. However, enzymatic peptide synthesis also proceeds in aqueous solutions. Due to their insolubility in water, groups like Fmoc or Z are not optimal for the aqueous reaction media, especially...
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| Veröffentlicht in: | Annals of the New York Academy of Sciences 1990, Vol.613 (1), p.633-637 |
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| container_title | Annals of the New York Academy of Sciences |
| container_volume | 613 |
| creator | FLÖRSHEIMER, A. SCHWARZ, A. STEINKE, D. KITTELMANN, M. HERRMANN, G. KULA, M. R. WANDREY, C. |
| description | In chemical peptide synthesis, various protecting groups have been optimized for application in organic media. However, enzymatic peptide synthesis also proceeds in aqueous solutions. Due to their insolubility in water, groups like Fmoc or Z are not optimal for the aqueous reaction media, especially if the kinetically controlled approach is used. Our aim was to investigate different protecting groups with regard to their application in enzymatic peptide synthesis. |
| doi_str_mv | 10.1111/j.1749-6632.1990.tb18235.x |
| format | Article |
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Our aim was to investigate different protecting groups with regard to their application in enzymatic peptide synthesis.</description><subject>Amino Acid Sequence</subject><subject>Amino Acids</subject><subject>Analgesics - chemical synthesis</subject><subject>Carboxypeptidases - metabolism</subject><subject>Chymotrypsin - metabolism</subject><subject>Dipeptides - chemical synthesis</subject><subject>Endorphins - chemical synthesis</subject><subject>enzymatic synthesis</subject><subject>Indicators and Reagents</subject><subject>Molecular Sequence Data</subject><subject>Oligopeptides - chemical synthesis</subject><subject>Peptides - chemical synthesis</subject><subject>protecting groups</subject><issn>0077-8923</issn><issn>1749-6632</issn><isbn>0897666267</isbn><isbn>9780897666268</isbn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1PwkAQhjd-BAH9CSaNB2-ts93ulzeDCCaoJH4lXjbdstUitHV3ScBfbxsIV-cyh-edmcyD0AWGCDd1NY8wT2TIGIkjLCVEXmMRExqtD1B3jw5RD4TkjLGY8SPUBeA8FDImJ6jn3BwAxyLhHdSJgTMA2UV0aitvMl-Un8HIVqvaBXllA_9lgmH5u1mmvsiCqal9MTPB86ZsgCvcKTrO04UzZ7veR693w5fBOJw8je4HN5MwI4L4kEpCU5xiSeOESCZBspnGQLWJda4NJPmM5DmlieZU8FRqrTPApiEiYYbkpI8ut3trW_2sjPNqWbjMLBZpaaqVUwKafxIB_wYxw0AkFk3wehvMbOWcNbmqbbFM7UZhUK1pNVetTtXqVK1ptTOt1s3w-e7KSi_NbD-6s9nwcMsL5816j1P7rRgnnKr3x5F6Y9OPB3o7Voz8AQh7h6w</recordid><startdate>1990</startdate><enddate>1990</enddate><creator>FLÖRSHEIMER, A.</creator><creator>SCHWARZ, A.</creator><creator>STEINKE, D.</creator><creator>KITTELMANN, M.</creator><creator>HERRMANN, G.</creator><creator>KULA, M. 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| fulltext | fulltext |
| identifier | ISSN: 0077-8923 |
| ispartof | Annals of the New York Academy of Sciences, 1990, Vol.613 (1), p.633-637 |
| issn | 0077-8923 1749-6632 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80284480 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | Amino Acid Sequence Amino Acids Analgesics - chemical synthesis Carboxypeptidases - metabolism Chymotrypsin - metabolism Dipeptides - chemical synthesis Endorphins - chemical synthesis enzymatic synthesis Indicators and Reagents Molecular Sequence Data Oligopeptides - chemical synthesis Peptides - chemical synthesis protecting groups |
| title | Protecting Groups for the Enzymatic Peptide Synthesis |
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