Protecting Groups for the Enzymatic Peptide Synthesis

Protecting Groups for the Enzymatic Peptide Synthesis

In chemical peptide synthesis, various protecting groups have been optimized for application in organic media. However, enzymatic peptide synthesis also proceeds in aqueous solutions. Due to their insolubility in water, groups like Fmoc or Z are not optimal for the aqueous reaction media, especially...

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Veröffentlicht in:Annals of the New York Academy of Sciences 1990, Vol.613 (1), p.633-637
Hauptverfasser: FLÖRSHEIMER, A., SCHWARZ, A., STEINKE, D., KITTELMANN, M., HERRMANN, G., KULA, M. R., WANDREY, C.
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acid Sequence
Amino Acids
Analgesics - chemical synthesis
Carboxypeptidases - metabolism
Chymotrypsin - metabolism
Dipeptides - chemical synthesis
Endorphins - chemical synthesis
enzymatic synthesis
Indicators and Reagents
Molecular Sequence Data
Oligopeptides - chemical synthesis
Peptides - chemical synthesis
protecting groups
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Beschreibung
Zusammenfassung:In chemical peptide synthesis, various protecting groups have been optimized for application in organic media. However, enzymatic peptide synthesis also proceeds in aqueous solutions. Due to their insolubility in water, groups like Fmoc or Z are not optimal for the aqueous reaction media, especially if the kinetically controlled approach is used. Our aim was to investigate different protecting groups with regard to their application in enzymatic peptide synthesis.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.1990.tb18235.x