Synthesis of C-(β- d-glycosyl) analogues of 3-deoxy- d- manno-2-octulosonic acid (Kdo) as potential inhibitors of CMP-Kdo synthetase

Eight C-(β- d-glycosyl) analogues ( 14–21) of Kdo (3-deoxy- d- manno-2-octulosonic acid) were obtained from isopropylidene-protected ester precursors and tested in vitro for their inhibitory activity on CMP-Kdo synthetase. None had more than minor inhibitory activity.

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Bibliographische Detailangaben
Veröffentlicht in:	Carbohydrate research 1990-10, Vol.206 (2), p.269-276
Hauptverfasser:	W»glund, Tommy, Luthman, Kristina, Orbe, Martin, Claesson, Alf
Format:	Artikel
Sprache:	eng
Schlagworte:	Carbohydrate Conformation Magnetic Resonance Spectroscopy Methods Molecular Structure Nucleotidyltransferases - antagonists & inhibitors Sugar Acids - chemical synthesis Sugar Acids - chemistry Sugar Acids - pharmacology
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Beschreibung
Zusammenfassung:	Eight C-(β- d-glycosyl) analogues ( 14–21) of Kdo (3-deoxy- d- manno-2-octulosonic acid) were obtained from isopropylidene-protected ester precursors and tested in vitro for their inhibitory activity on CMP-Kdo synthetase. None had more than minor inhibitory activity.
ISSN:	0008-6215 1873-426X
DOI:	10.1016/0008-6215(90)80066-C