Molecular forms of butyrylcholinesterase in rat brain microvessels

Molecular forms of butyrylcholinesterase (BuChE) were studied in microvessels isolated from rat brain, using sedimentation analysis in sucrose gradients. Three forms, G 1, G 2 and G 4, were found with sedimentation coefficients close to 3S, 6S and 9S, respectively. The relative proportion of the 3 f...

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Veröffentlicht in:	Neuroscience letters 1990-11, Vol.120 (1), p.46-49
Hauptverfasser:	EDGARDO CATALAN, R, MARTINEZ, A. M, ARAGONES, M. D, HERNANDEZ, F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood-brain barrier Brain microvessel Butyrylcholinesterase Butyrylcholinesterase - analysis Capillaries - enzymology Centrifugation, Density Gradient Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges Cerebrovascular Circulation Fundamental and applied biological sciences. Psychology Macromolecular Substances Male Molecular form Molecular Weight Muscle, Smooth, Vascular - enzymology Rats Rats, Inbred Strains Vertebrates: nervous system and sense organs
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Zusammenfassung:	Molecular forms of butyrylcholinesterase (BuChE) were studied in microvessels isolated from rat brain, using sedimentation analysis in sucrose gradients. Three forms, G 1, G 2 and G 4, were found with sedimentation coefficients close to 3S, 6S and 9S, respectively. The relative proportion of the 3 forms was 19% for the monomer, 33% for the dimer and 46% for the tetramer. This sedimentation pattern of BuChE forms appears to be characteristic of cerebral microvessels and may represent distinct functional features of the blood-brain barrier.
ISSN:	0304-3940 1872-7972
DOI:	10.1016/0304-3940(90)90164-5