Hepatic aging as an etiological factor in the development of Alzheimer's disease
Alzheimer's disease is a frequent cause of dementia in the elderly. The prevalence and incidence increase with aging. It is hypothesised that the age related decline in liver size and lysosomal function results in decreased clearance as well as decreased or altered proteolysis of the Alzheimer...
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| Veröffentlicht in: | Medical hypotheses 1990-11, Vol.33 (3), p.163-167 |
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| container_title | Medical hypotheses |
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| creator | Fisman, M. |
| description | Alzheimer's disease is a frequent cause of dementia in the elderly. The prevalence and incidence increase with aging. It is hypothesised that the age related decline in liver size and lysosomal function results in decreased clearance as well as decreased or altered proteolysis of the Alzheimer precursor protein, and results in the deposition of A4 protein in cerebral blood vessels and brain with congophilic angiopathy and senile/amyloid plaque formation. |
| doi_str_mv | 10.1016/0306-9877(90)90168-E |
| format | Article |
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The prevalence and incidence increase with aging. 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| fulltext | fulltext |
| identifier | ISSN: 0306-9877 |
| ispartof | Medical hypotheses, 1990-11, Vol.33 (3), p.163-167 |
| issn | 0306-9877 1532-2777 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80270953 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Aging - physiology Alzheimer Disease - complications Alzheimer Disease - etiology Alzheimer Disease - physiopathology Amyloid - metabolism Dementia, Vascular - complications Humans Liver - physiopathology Lysosomes - metabolism Male Middle Aged Models, Biological |
| title | Hepatic aging as an etiological factor in the development of Alzheimer's disease |
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