Hepatic aging as an etiological factor in the development of Alzheimer's disease

Hepatic aging as an etiological factor in the development of Alzheimer's disease

Alzheimer's disease is a frequent cause of dementia in the elderly. The prevalence and incidence increase with aging. It is hypothesised that the age related decline in liver size and lysosomal function results in decreased clearance as well as decreased or altered proteolysis of the Alzheimer...

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Veröffentlicht in:Medical hypotheses 1990-11, Vol.33 (3), p.163-167
1. Verfasser: Fisman, M.
Format: Artikel
Sprache:eng
Schlagworte:
Aging - physiology
Alzheimer Disease - complications
Alzheimer Disease - etiology
Alzheimer Disease - physiopathology
Amyloid - metabolism
Dementia, Vascular - complications
Humans
Liver - physiopathology
Lysosomes - metabolism
Male
Middle Aged
Models, Biological
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Zusammenfassung:Alzheimer's disease is a frequent cause of dementia in the elderly. The prevalence and incidence increase with aging. It is hypothesised that the age related decline in liver size and lysosomal function results in decreased clearance as well as decreased or altered proteolysis of the Alzheimer precursor protein, and results in the deposition of A4 protein in cerebral blood vessels and brain with congophilic angiopathy and senile/amyloid plaque formation.
ISSN:0306-9877
1532-2777
DOI:10.1016/0306-9877(90)90168-E