CAF-603: A New Antifungal Carotane Sesquiterpene. Isolation and Structure Elucidation
A new antifungal compound, CAF-603, was isolated from the culture broth of Gliocladium virens IFO 9166. The structure of compound 1 has been elucidated by spectroscopic methods that also allowed the relative stereochemistry to be assigned. CAF-603 [1] was active against yeasts and dermatophytes.
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| Veröffentlicht in: | Journal of natural products (Washington, D.C.) D.C.), 1990-09, Vol.53 (5), p.1176-1181 |
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| container_end_page | 1181 |
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| container_issue | 5 |
| container_start_page | 1176 |
| container_title | Journal of natural products (Washington, D.C.) |
| container_volume | 53 |
| creator | Watanabe, Naoharu Yamagishi, Michio Mizutani, Taku Kondoh, Hideaki Omura, Sadafumi Hanada, Kazunori Kushida, Katsuhiko |
| description | A new antifungal compound, CAF-603, was isolated from the culture broth of Gliocladium virens IFO 9166. The structure of compound 1 has been elucidated by spectroscopic methods that also allowed the relative stereochemistry to be assigned. CAF-603 [1] was active against yeasts and dermatophytes. |
| doi_str_mv | 10.1021/np50071a006 |
| format | Article |
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CAF-603 [1] was active against yeasts and dermatophytes.</description><identifier>ISSN: 0163-3864</identifier><identifier>EISSN: 1520-6025</identifier><identifier>DOI: 10.1021/np50071a006</identifier><identifier>PMID: 2292685</identifier><identifier>CODEN: JNPRDF</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>ANTIBIOTICOS ; ANTIBIOTICS ; Antibiotics (antibacterial agents, antifungal agents) ; Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents ; ANTIBIOTIQUE ; Antifungal Agents - isolation & purification ; ANTIFUNGAL PROPERTIES ; Applied microbiology ; Biological and medical sciences ; CANDIDA ALBICANS ; Candida albicans - drug effects ; CHAMPIGNON ; DERMATOPHYTES ; Fundamental and applied biological sciences. Psychology ; FUNGI ; Fungi - drug effects ; GLIOCLADIUM ; GLIOCLADIUM VIRENS ; HONGOS ; LEVADURA ; LEVURE ; Magnetic Resonance Spectroscopy ; Microbiology ; Mitosporic Fungi - analysis ; MOLECULAR CONFORMATION ; Molecular Structure ; PROPIEDADES ANTIMICOSICAS ; PROPRIETE ANTIFONGIQUE ; Sesquiterpenes - pharmacology ; SESQUITERPENOIDE ; SESQUITERPENOIDS ; SESQUITERPENOS ; YEASTS</subject><ispartof>Journal of natural products (Washington, D.C.), 1990-09, Vol.53 (5), p.1176-1181</ispartof><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a469t-cfaf57bf90f609f9c0d32b17a8242b0b6223c9c85a2ffad85d0eec10eaac3893</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/np50071a006$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/np50071a006$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2751,27055,27903,27904,56717,56767</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19474189$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2292685$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Watanabe, Naoharu</creatorcontrib><creatorcontrib>Yamagishi, Michio</creatorcontrib><creatorcontrib>Mizutani, Taku</creatorcontrib><creatorcontrib>Kondoh, Hideaki</creatorcontrib><creatorcontrib>Omura, Sadafumi</creatorcontrib><creatorcontrib>Hanada, Kazunori</creatorcontrib><creatorcontrib>Kushida, Katsuhiko</creatorcontrib><title>CAF-603: A New Antifungal Carotane Sesquiterpene. Isolation and Structure Elucidation</title><title>Journal of natural products (Washington, D.C.)</title><addtitle>J. Nat. Prod</addtitle><description>A new antifungal compound, CAF-603, was isolated from the culture broth of Gliocladium virens IFO 9166. The structure of compound 1 has been elucidated by spectroscopic methods that also allowed the relative stereochemistry to be assigned. CAF-603 [1] was active against yeasts and dermatophytes.</description><subject>ANTIBIOTICOS</subject><subject>ANTIBIOTICS</subject><subject>Antibiotics (antibacterial agents, antifungal agents)</subject><subject>Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents</subject><subject>ANTIBIOTIQUE</subject><subject>Antifungal Agents - isolation & purification</subject><subject>ANTIFUNGAL PROPERTIES</subject><subject>Applied microbiology</subject><subject>Biological and medical sciences</subject><subject>CANDIDA ALBICANS</subject><subject>Candida albicans - drug effects</subject><subject>CHAMPIGNON</subject><subject>DERMATOPHYTES</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>FUNGI</subject><subject>Fungi - drug effects</subject><subject>GLIOCLADIUM</subject><subject>GLIOCLADIUM VIRENS</subject><subject>HONGOS</subject><subject>LEVADURA</subject><subject>LEVURE</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Microbiology</subject><subject>Mitosporic Fungi - analysis</subject><subject>MOLECULAR CONFORMATION</subject><subject>Molecular Structure</subject><subject>PROPIEDADES ANTIMICOSICAS</subject><subject>PROPRIETE ANTIFONGIQUE</subject><subject>Sesquiterpenes - pharmacology</subject><subject>SESQUITERPENOIDE</subject><subject>SESQUITERPENOIDS</subject><subject>SESQUITERPENOS</subject><subject>YEASTS</subject><issn>0163-3864</issn><issn>1520-6025</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkMFv0zAYxS0EGt3gxA0JyRfGYcr4bMdOzK0qW5lUDbR2XK0vjj1lpElnxwL-e7Kl2nbg9A6_n56eHiHvGJwy4Oxzt5MABUMA9YLMmOSQKeDyJZkBUyITpcpfk8MYbwFAgJYH5IBzzVUpZ-R6MT8fbfGFzuml-03n3dD41N1gSxcY-gE7R9cu3qVmcGHnOndKL2Lf4tD0HcWupushJDuk4OhZm2xTP5A35JXHNrq3-zwim_OzzeJbtvq-vFjMVxnmSg-Z9ehlUXkNXoH22kIteMUKLHnOK6gU58JqW0rk3mNdyhqcswwcohWlFkfkeKrdhf4uuTiYbROta9txdZ-iKYErrQo1iieTaEMfY3De7EKzxfDXMDD3H5pnH472h31tqraufnT3p438455jtNj6gJ1t4lOlzoucPczLJq-Jg_vzyDH8MqoQhTSbH2uzvPp5ebVZfTXL0X8_-R57gzdh7Lxea8FLyYoRfpog2mhu-xS68dj_zv8HaTmcjw</recordid><startdate>19900901</startdate><enddate>19900901</enddate><creator>Watanabe, Naoharu</creator><creator>Yamagishi, Michio</creator><creator>Mizutani, Taku</creator><creator>Kondoh, Hideaki</creator><creator>Omura, Sadafumi</creator><creator>Hanada, Kazunori</creator><creator>Kushida, Katsuhiko</creator><general>American Chemical Society</general><general>American Society of Pharmacognosy</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19900901</creationdate><title>CAF-603: A New Antifungal Carotane Sesquiterpene. Isolation and Structure Elucidation</title><author>Watanabe, Naoharu ; Yamagishi, Michio ; Mizutani, Taku ; Kondoh, Hideaki ; Omura, Sadafumi ; Hanada, Kazunori ; Kushida, Katsuhiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a469t-cfaf57bf90f609f9c0d32b17a8242b0b6223c9c85a2ffad85d0eec10eaac3893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>ANTIBIOTICOS</topic><topic>ANTIBIOTICS</topic><topic>Antibiotics (antibacterial agents, antifungal agents)</topic><topic>Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents</topic><topic>ANTIBIOTIQUE</topic><topic>Antifungal Agents - isolation & purification</topic><topic>ANTIFUNGAL PROPERTIES</topic><topic>Applied microbiology</topic><topic>Biological and medical sciences</topic><topic>CANDIDA ALBICANS</topic><topic>Candida albicans - drug effects</topic><topic>CHAMPIGNON</topic><topic>DERMATOPHYTES</topic><topic>Fundamental and applied biological sciences. 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Isolation and Structure Elucidation</atitle><jtitle>Journal of natural products (Washington, D.C.)</jtitle><addtitle>J. Nat. Prod</addtitle><date>1990-09-01</date><risdate>1990</risdate><volume>53</volume><issue>5</issue><spage>1176</spage><epage>1181</epage><pages>1176-1181</pages><issn>0163-3864</issn><eissn>1520-6025</eissn><coden>JNPRDF</coden><abstract>A new antifungal compound, CAF-603, was isolated from the culture broth of Gliocladium virens IFO 9166. The structure of compound 1 has been elucidated by spectroscopic methods that also allowed the relative stereochemistry to be assigned. CAF-603 [1] was active against yeasts and dermatophytes.</abstract><cop>Washington, DC</cop><cop>Glendale, AZ</cop><pub>American Chemical Society</pub><pmid>2292685</pmid><doi>10.1021/np50071a006</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0163-3864 |
| ispartof | Journal of natural products (Washington, D.C.), 1990-09, Vol.53 (5), p.1176-1181 |
| issn | 0163-3864 1520-6025 |
| language | eng |
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| source | MEDLINE; American Chemical Society Journals |
| subjects | ANTIBIOTICOS ANTIBIOTICS Antibiotics (antibacterial agents, antifungal agents) Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents ANTIBIOTIQUE Antifungal Agents - isolation & purification ANTIFUNGAL PROPERTIES Applied microbiology Biological and medical sciences CANDIDA ALBICANS Candida albicans - drug effects CHAMPIGNON DERMATOPHYTES Fundamental and applied biological sciences. Psychology FUNGI Fungi - drug effects GLIOCLADIUM GLIOCLADIUM VIRENS HONGOS LEVADURA LEVURE Magnetic Resonance Spectroscopy Microbiology Mitosporic Fungi - analysis MOLECULAR CONFORMATION Molecular Structure PROPIEDADES ANTIMICOSICAS PROPRIETE ANTIFONGIQUE Sesquiterpenes - pharmacology SESQUITERPENOIDE SESQUITERPENOIDS SESQUITERPENOS YEASTS |
| title | CAF-603: A New Antifungal Carotane Sesquiterpene. Isolation and Structure Elucidation |
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