CAF-603: A New Antifungal Carotane Sesquiterpene. Isolation and Structure Elucidation

A new antifungal compound, CAF-603, was isolated from the culture broth of Gliocladium virens IFO 9166. The structure of compound 1 has been elucidated by spectroscopic methods that also allowed the relative stereochemistry to be assigned. CAF-603 [1] was active against yeasts and dermatophytes.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 1990-09, Vol.53 (5), p.1176-1181
Hauptverfasser:	Watanabe, Naoharu, Yamagishi, Michio, Mizutani, Taku, Kondoh, Hideaki, Omura, Sadafumi, Hanada, Kazunori, Kushida, Katsuhiko
Format:	Artikel
Sprache:	eng
Schlagworte:	ANTIBIOTICOS ANTIBIOTICS Antibiotics (antibacterial agents, antifungal agents) Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents ANTIBIOTIQUE Antifungal Agents - isolation & purification ANTIFUNGAL PROPERTIES Applied microbiology Biological and medical sciences CANDIDA ALBICANS Candida albicans - drug effects CHAMPIGNON DERMATOPHYTES Fundamental and applied biological sciences. Psychology FUNGI Fungi - drug effects GLIOCLADIUM GLIOCLADIUM VIRENS HONGOS LEVADURA LEVURE Magnetic Resonance Spectroscopy Microbiology Mitosporic Fungi - analysis MOLECULAR CONFORMATION Molecular Structure PROPIEDADES ANTIMICOSICAS PROPRIETE ANTIFONGIQUE Sesquiterpenes - pharmacology SESQUITERPENOIDE SESQUITERPENOIDS SESQUITERPENOS YEASTS
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Beschreibung
Zusammenfassung:	A new antifungal compound, CAF-603, was isolated from the culture broth of Gliocladium virens IFO 9166. The structure of compound 1 has been elucidated by spectroscopic methods that also allowed the relative stereochemistry to be assigned. CAF-603 [1] was active against yeasts and dermatophytes.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np50071a006