Loss of rat ventricular alpha 1-adrenergic receptors during aging

Ventricular alpha 1-adrenergic receptor concentration, measured by specific binding of [3H]-prazosin, decreases by 33% as rats age from 3 to 24 months. No age changes occur in binding affinity for [3H]-prazosin or potency of various alpha-adrenergic agonists and antagonists to displace [3H]-prazosin...

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Veröffentlicht in:	Life sciences (1973) 1982-11, Vol.31 (22), p.2507-2512
Hauptverfasser:	Partilla, J S, Hoopes, M T, Ito, H, Dax, E M, Roth, G S
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging alpha 1-adrenergic Animals Heart - physiology Heart Ventricles - metabolism Male Myocardium - metabolism Prazosin - metabolism Rats Rats, Inbred Strains Receptors, Adrenergic - metabolism Receptors, Adrenergic, alpha - metabolism ventricles (cerebral)
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Zusammenfassung:	Ventricular alpha 1-adrenergic receptor concentration, measured by specific binding of [3H]-prazosin, decreases by 33% as rats age from 3 to 24 months. No age changes occur in binding affinity for [3H]-prazosin or potency of various alpha-adrenergic agonists and antagonists to displace [3H]-prazosin. The ratio of membrane protein to ventricular wet weight also does not change significantly with age. These results suggest a possible mechanism for loss of cardiovascular alpha-adrenergic responsiveness during aging.
ISSN:	0024-3205
DOI:	10.1016/0024-3205(82)90757-3