Mumps Virus-persistently Infected Cell Cultures Release Defective Interfering Virus Particles

Research Institute for Viral Preparations, Moscow 109088, U.S.S.R. Two human cell cultures, HEp-2 and L-41, persistently infected with mumps virus, produced small amounts of slowly replicating small-plaque infectious virus and detectable amounts of defective interfering virus particles which were si...

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Veröffentlicht in:	Journal of general virology 1982-12, Vol.63 (2), p.499-503
Hauptverfasser:	Andzhaparidze, O. G, Boriskin, Yu. S, Bogomolova, N. N, Drynov, I. D
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line Defective Viruses - physiology Humans mumps virus Mumps virus - analysis Mumps virus - physiology RNA, Viral - analysis Viral Interference Viral Plaque Assay Viral Proteins - analysis Virus Replication
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Zusammenfassung:	Research Institute for Viral Preparations, Moscow 109088, U.S.S.R. Two human cell cultures, HEp-2 and L-41, persistently infected with mumps virus, produced small amounts of slowly replicating small-plaque infectious virus and detectable amounts of defective interfering virus particles which were similar to standard mumps virus in polypeptide composition, contained subgenomic size RNAs and interfered with standard mumps virus replication in susceptible cells. Keywords: mumps virus, persistence, defective virus particles Received 25 March 1982; accepted 8 July 1982.
ISSN:	0022-1317 1465-2099
DOI:	10.1099/0022-1317-63-2-499