Acylureido penicillins in neonatal intensive care. Preliminary communication

The antimicrobial sensitivity of 232 bacteria isolated from patients in a newborn intensive care unit was tested. Practically all organisms were sensitive to a combination of mezlocillin-aminoglycoside; a few were resistant to azlocillin-aminoglycoside. Eighteen patients, all severely ill, were treated with the combination acylureidopenicillin-aminoglycoside. Nine patients died, eight due to non-infectious diseases and one very small premature baby due to Serratia marcescens meningitis. The other patients showed good clinical improvement. The only side-effect observed was a macular rash in one patient.