Plasma Norepinephrine in the Evaluation of Baroreceptor Function in Humans

The value of plasma norepinephrine measurement in assessing baroreceptor-mediated changes in sympathetic vasomotor activity was studied in seven healthy normotensive volunteers. Blood pressure was decreased by graded steady-state infusions of sodium nitroprusside (25–100 μg/min) and increased by inf...

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Veröffentlicht in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 1982-07, Vol.4 (4), p.566-571
Hauptverfasser: GROSSMAN, STEVEN H, DAVIS, DWIGHT, GUNNELLS, J CAULIE, SHAND, DAVID G
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Sprache:eng
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Zusammenfassung:The value of plasma norepinephrine measurement in assessing baroreceptor-mediated changes in sympathetic vasomotor activity was studied in seven healthy normotensive volunteers. Blood pressure was decreased by graded steady-state infusions of sodium nitroprusside (25–100 μg/min) and increased by infusions of phenylephrine (25–100 μ/) at rates producing a 10° to 20° change in diastolic blood pressure. Sodium nitroprusside produced significant decreases in diastolic blood pressure (p < 0.01) and calculated mean arterial blood pressure (p < 0.005), and increases in heart rate (p < 0.001) and plasma norepinephrine (p < 0.001). Phenylephrine administration produced increases in systolic (p < 0.005), diastolic (p < 0.005), and mean blood pressure (p < 0.001). Heart rate (p < 0.001) and plasma norepinephrine (p < 0.05) fell. The absolute changes in diastolic and mean pressure and heart rate were not significantly different for the two drugs, but were of opposite sign; however, the increase in plasma norepinephrine during hypotension was greater than the decrease during hypertension (p = 0.02). We conclude that plasma norepinephrine changes appropriately in response to altered blood pressure and that the response is greater to a given fall than to a rise in blood pressure, consistent with known changes in sympathetic vasomotor outflow. (Hypertension 4:566–571, 1982)
ISSN:0194-911X
1524-4563
DOI:10.1161/01.hyp.4.4.566