Cell-surface and secreted proteinases and guanidinobenzoatase activity

Hydrolysis of p-nitrophenyl guanidinobenzoate is characteristic of a tumour cell surface proteinase. We found this activity in three transformed or tumour cell lines, but not in two normal fibroblast strains. Immunochemical inhibition of plasminogen activator activity did not affect guanidinobenzoat...

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Veröffentlicht in:	Bioscience reports 1990-10, Vol.10 (5), p.469-472
Hauptverfasser:	Perry, J K, Scott, G K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carboxylic Ester Hydrolases - analysis Cell Line, Transformed Endopeptidases HeLa Cells Humans Hydrolysis L Cells (Cell Line) Mice Plasminogen Activators - analysis Plasminogen Activators - biosynthesis Tissue Plasminogen Activator - analysis Tissue Plasminogen Activator - biosynthesis Transforming Growth Factors - metabolism Tumor Cells, Cultured
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Zusammenfassung:	Hydrolysis of p-nitrophenyl guanidinobenzoate is characteristic of a tumour cell surface proteinase. We found this activity in three transformed or tumour cell lines, but not in two normal fibroblast strains. Immunochemical inhibition of plasminogen activator activity did not affect guanidinobenzoatase activity.
ISSN:	0144-8463 1573-4935
DOI:	10.1007/BF01152294