Phosphorylation—dephosphorylation of purified insulin receptor from human placenta: Effect of insulin

The insulin receptor of human placenta even after extensive purification is phosphorylated in the presence of [γ- 32P]ATP and NaF, and is dephosphorylated again on incubation in NaF-free medium. Insulin stimulates phosphate incorporation into the M r95 000 subunit probably by activation of the phosp...

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Veröffentlicht in:	FEBS letters 1982-11, Vol.149 (1), p.96-100
Hauptverfasser:	Machicao, F., Urumow, T., Wieland, O.H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Female Humans insulin Insulin - analogs & derivatives Insulin - metabolism Insulin - pharmacology Insulin action Insulin receptor Kinetics man Molecular Weight Phosphorus Radioisotopes Phosphorylation Placenta Placenta - metabolism Pregnancy Receptor, Insulin - drug effects Receptor, Insulin - metabolism Receptors, Estrogen - isolation & purification
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