The structure of the homeodomain and its functional implications

The three-dimensional structure of the homeodomain, as determined by nuclear magnetic resonance spectroscopy, reveals the presence of a helix-turn-helix motif, similar to the one found in prokaryotic gene regulatory proteins. Isolated homeodomains bind with high affinity to specific DNA sequences. T...

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Veröffentlicht in:	Trends in Genetics 1990, Vol.6 (10), p.323-329
Hauptverfasser:	Gehring, W.J., Müller, M., Affolter, M., Percival-Smith, A., Billeter, M., Qian, Y.Q., Otting, G., Wüthrich, K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Base Sequence Biological Evolution DNA - genetics DNA - metabolism Drosophila - anatomy & histology Drosophila - genetics Genes, Homeobox Molecular Sequence Data Protein Conformation
Online-Zugang:	Volltext
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Zusammenfassung:	The three-dimensional structure of the homeodomain, as determined by nuclear magnetic resonance spectroscopy, reveals the presence of a helix-turn-helix motif, similar to the one found in prokaryotic gene regulatory proteins. Isolated homeodomains bind with high affinity to specific DNA sequences. Thus, the structure-function relationship is highly conserved in evolution.
ISSN:	0168-9525
DOI:	10.1016/0168-9525(90)90253-3