Regulation of Drosophila folylpolyglutamates during development

The polyglutamate status of reduced folates during the larval, pupal and adult stages of Drosophila melanogaster development was investigated. The chain length distribution is very similar and is predominantly pentaglutamate. Half-life estimates of the hydrolytic degradation to the monoglutamate sho...

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Veröffentlicht in:	Molecular and cellular biochemistry 1990-09, Vol.97 (2), p.187-188
Hauptverfasser:	Duke, E.J. (University College Dublin, Dublin, Ireland), Priest, D.G
Format:	Artikel
Sprache:	eng
Schlagworte:	ACIDE FOLIQUE ACIDE GLUTAMIQUE ACIDO FOLICO ACIDO GLUTAMICO ACTIVIDAD ENZIMATICA ACTIVITE ENZYMATIQUE Animals BIOLOGICAL DEVELOPMENT Cells, Cultured DESARROLLO BIOLOGICO DEVELOPPEMENT BIOLOGIQUE Diptera DROSOPHILA MELANOGASTER Drosophila melanogaster - growth & development Drosophila melanogaster - metabolism Drosophilidae ENZYMIC ACTIVITY FOLIC ACID Folic Acid - metabolism GLUTAMIC ACID HIDROLASAS HYDROLASE HYDROLASES Hydrolysis PENTAGLUTAMATE POLYGLUTAMATE HYDROLASE Polyglutamic Acid - metabolism
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Zusammenfassung:	The polyglutamate status of reduced folates during the larval, pupal and adult stages of Drosophila melanogaster development was investigated. The chain length distribution is very similar and is predominantly pentaglutamate. Half-life estimates of the hydrolytic degradation to the monoglutamate showed larva less than pupa less than adult. This raises the possibility that polyglutamate hydrolase may have a role in regulating the total intracellular reduced folate content of the different developmental stages.
ISSN:	0300-8177 1573-4919
DOI:	10.1007/BF00221061