Igm anticoagulant with acquired abnormalities in factor VIII

The effects of an IgM lupus anticoagulant on coagulation tests and factor VIII related antigen (FVIIIR:Ag) were investigated in a 62 year old man with lymphocytic lymphoma. He experienced no abnormal bleeding despite a prothrombin time of 29 seconds, PTT 84 seconds and inhibition of multiple coagula...

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Veröffentlicht in:	Thrombosis research 1982-09, Vol.27 (6), p.703-712
1. Verfasser:	Abe Andes, W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens - analysis Blood Coagulation Disorders - blood Blood Coagulation Disorders - diagnosis Blood Coagulation Disorders - drug therapy Blood Coagulation Factors - analysis Blood Coagulation Factors - antagonists & inhibitors Factor IX - analysis factor VIII Factor VIII - analysis Factor VIII - immunology Factor XI - analysis Humans IgM Immunoelectrophoresis, Two-Dimensional Immunoglobulin M lupus anticoagulant Lupus Coagulation Inhibitor Male Middle Aged Partial Thromboplastin Time Platelet Aggregation - drug effects von Willebrand Factor
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Zusammenfassung:	The effects of an IgM lupus anticoagulant on coagulation tests and factor VIII related antigen (FVIIIR:Ag) were investigated in a 62 year old man with lymphocytic lymphoma. He experienced no abnormal bleeding despite a prothrombin time of 29 seconds, PTT 84 seconds and inhibition of multiple coagulation factors. One course of chemotherapy induced a clinical response, normalization of coagulation studies and a rapid fall in IgM from 1120 to
ISSN:	0049-3848 1879-2472
DOI:	10.1016/0049-3848(82)90008-1