Influence of Diphenylhydantoin on Isotope Release and Bone Enzymes In Vitro

The acute effect of diphenylhydantoin on isotope release in an in vitro system using mouse calvaries was studied. A depressive effect on bone resorption was found involving radioactive calcium as well as tritiated proline. Bone resorption and formation were further investigated by semiquantitative h...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Acta orthopaedica 1982, Vol.53 (6), p.885-888
Hauptverfasser:	Pedersen, J. G., Lund, B. J., Reimann, I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid Phosphatase - metabolism Alkaline Phosphatase - metabolism Animals bone Bone and Bones - drug effects Bone and Bones - enzymology Bone Resorption - drug effects Calcium - metabolism Calcium Radioisotopes diphenylhydantoin enzymes histocytochemistry In Vitro Techniques isotopes Mice Phenytoin - pharmacology Proline - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The acute effect of diphenylhydantoin on isotope release in an in vitro system using mouse calvaries was studied. A depressive effect on bone resorption was found involving radioactive calcium as well as tritiated proline. Bone resorption and formation were further investigated by semiquantitative hístochemistry. Depressed activity of both alkaline and acid phosphatase was found, indicating a direct inhibitory effect of diphenylhydantoin on bone turnover.
ISSN:	1745-3674 0001-6470 1745-3682
DOI:	10.3109/17453678208992843