Successful treatment of Candida osteomyelitis with fluconazole: A noncomparative study of two patients

We describe two patients with osteomyelitis due to Candida spp. treated with fluconazole, a new triazole antifungal. One patient had extensive involvement of ribs and costochondral regions of the anterior chest, and the other had vertebral infection. Both were cured with courses of 10 and 14 months,...

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Veröffentlicht in:	Diagnostic microbiology and infectious disease 1990-11, Vol.13 (6), p.517-520
Hauptverfasser:	Sugar, Alan M., Saunders, Carol, Diamond, Richard D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Biological and medical sciences Candidiasis - drug therapy Drug Tolerance Fluconazole - therapeutic use Humans Male Medical sciences Osteomyelitis - drug therapy Pharmacology. Drug treatments Ribs Spine
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Zusammenfassung:	We describe two patients with osteomyelitis due to Candida spp. treated with fluconazole, a new triazole antifungal. One patient had extensive involvement of ribs and costochondral regions of the anterior chest, and the other had vertebral infection. Both were cured with courses of 10 and 14 months, with ⩾ 1 year of follow-up after fluconazole was discontinued. Fluconazole is an attractive agent for the treatment of Candida osteomyelitis and deserves to be studied more extensively for this indication.
ISSN:	0732-8893 1879-0070
DOI:	10.1016/0732-8893(90)90084-9