Anti-inflammatory constituents of topically applied crude drugs. IV, Constituents and anti-inflammatory effect of Paraguayan crude drug alhucema] (Lavandula latifolia VILL.)

The anti-inflammatory active fraction of the Paraguayan crude drug, "Alhucema," Lavandula latifolia Vill. afforded four compounds: coumarin (1), 7-methoxycoumarin (2), trans-phytol (3) and caryophyllene oxide (4). 1 showed a weakly inhibitory effect on carrageenin-induced paw edema in rats...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1990, Vol.38 (8), p.2283-2284
Hauptverfasser:	SHIMIZU, M, SHOGAWA, H, BASUALDO, I, BERGANZA, L. H, MATSUZAWA, T, YONEZAWA, S, HAYASHI, T, ARISAWA, M, SUZUKI, S, YOSHIZAKI, M, MORITA, N, FERRO, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - analysis Biological and medical sciences Biological Assay Coumarins - analysis General pharmacology Guinea Pigs In Vitro Techniques Medical sciences Paraguay Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytol - analysis Plants, Medicinal - analysis Rats Sesquiterpenes - analysis
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Zusammenfassung:	The anti-inflammatory active fraction of the Paraguayan crude drug, "Alhucema," Lavandula latifolia Vill. afforded four compounds: coumarin (1), 7-methoxycoumarin (2), trans-phytol (3) and caryophyllene oxide (4). 1 showed a weakly inhibitory effect on carrageenin-induced paw edema in rats on topical application and 4 showed an inhibitory effect on histamine-induced contraction in guinea pig ileum.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.38.2283