IN VITRO AND IN VIVO ANTIMICROBIAL ACTIVITIES OF CEFMETAZOLE AGAINST BACTEROIDES FRAGILIS

Cefmetazole was investigated on stability to β-lactamases produced by Bacteroides fragilis and on therapeutic effects in mice infected with B.fragilis. 1.Cefmetazole, like other cephamycins, was found extremely stable to β-lactamases obtained from B.fragilis. 2.Cefmetazole showed good antimicrobial activities to 50 strains of B.fragilis and extremely high stability to their β-lactamases. 3.Cefmetazole showed an excellent protecting effect to infections due to β-lactamase producing B.fragilis. 4.Cefmetazole exhibited an excellent chemotherapeutic effect against polymicrobial infections in mice due to E.coli (β-lactamase-) and B.fragilis (β-lactamase+).