Glucose Metabolism of Isolated Glomeruli of Rats with Masugi Nephritis
Renal glomeruli were isolated from the rats 4 days after injection of nephrotoxic serum. In an early stage of Masugi nephritis, decarboxylation of 1-14C and 6-14C-glucose, LDH, G6PDH and 6PGDH activities and glycolysis were investigated in the isolated glomeruli. The ratio of 14C-1/14C-6 liberated f...
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| Veröffentlicht in: | Nihon Jinzo Gakkai shi 1982/06/25, Vol.24(6), pp.591-598 |
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| container_title | Nihon Jinzo Gakkai shi |
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| creator | Yoneda, Seiichi Maeda, Masaaki Yasumi, Masahito Kimura, Izumi Nakamura, Kikuo Minaga, Takeyoshi Kizu, Akira Ijichi, Hamao |
| description | Renal glomeruli were isolated from the rats 4 days after injection of nephrotoxic serum. In an early stage of Masugi nephritis, decarboxylation of 1-14C and 6-14C-glucose, LDH, G6PDH and 6PGDH activities and glycolysis were investigated in the isolated glomeruli. The ratio of 14C-1/14C-6 liberated from labeled glucose was 4.13±0.60 in nephritic glomeruli, while 1.72±0.21 in normal glomeruli. All the enzyme activities mentioned above were significantly increased and glycolysis was accelerated in nephrotic glomeruli. These results indicated that both glycolysic pathway and pentose monophosphate pathway were activated in glomeruli of the rats with Masugi nephritis, and these phenomena may be responsible for the mechanism of repairment in damaged glomeruli. |
| doi_str_mv | 10.14842/jpnjnephrol1959.24.591 |
| format | Article |
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In an early stage of Masugi nephritis, decarboxylation of 1-14C and 6-14C-glucose, LDH, G6PDH and 6PGDH activities and glycolysis were investigated in the isolated glomeruli. The ratio of 14C-1/14C-6 liberated from labeled glucose was 4.13±0.60 in nephritic glomeruli, while 1.72±0.21 in normal glomeruli. All the enzyme activities mentioned above were significantly increased and glycolysis was accelerated in nephrotic glomeruli. These results indicated that both glycolysic pathway and pentose monophosphate pathway were activated in glomeruli of the rats with Masugi nephritis, and these phenomena may be responsible for the mechanism of repairment in damaged glomeruli.</description><identifier>ISSN: 0385-2385</identifier><identifier>EISSN: 1884-0728</identifier><identifier>DOI: 10.14842/jpnjnephrol1959.24.591</identifier><identifier>PMID: 7176174</identifier><language>jpn</language><publisher>Japan: Japanese Society of Nephrology</publisher><subject>Animals ; Disease Models, Animal ; Glomerulonephritis - metabolism ; Glucose - metabolism ; Glycolysis ; In Vitro Techniques ; Kidney Glomerulus - metabolism ; Male ; Rats ; Rats, Inbred Strains</subject><ispartof>The Japanese Journal of Nephrology, 1982/06/25, Vol.24(6), pp.591-598</ispartof><rights>Japanese Society of Nephrology</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,1877,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7176174$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yoneda, Seiichi</creatorcontrib><creatorcontrib>Maeda, Masaaki</creatorcontrib><creatorcontrib>Yasumi, Masahito</creatorcontrib><creatorcontrib>Kimura, Izumi</creatorcontrib><creatorcontrib>Nakamura, Kikuo</creatorcontrib><creatorcontrib>Minaga, Takeyoshi</creatorcontrib><creatorcontrib>Kizu, Akira</creatorcontrib><creatorcontrib>Ijichi, Hamao</creatorcontrib><title>Glucose Metabolism of Isolated Glomeruli of Rats with Masugi Nephritis</title><title>Nihon Jinzo Gakkai shi</title><addtitle>Jpn J Nephrol</addtitle><description>Renal glomeruli were isolated from the rats 4 days after injection of nephrotoxic serum. In an early stage of Masugi nephritis, decarboxylation of 1-14C and 6-14C-glucose, LDH, G6PDH and 6PGDH activities and glycolysis were investigated in the isolated glomeruli. The ratio of 14C-1/14C-6 liberated from labeled glucose was 4.13±0.60 in nephritic glomeruli, while 1.72±0.21 in normal glomeruli. All the enzyme activities mentioned above were significantly increased and glycolysis was accelerated in nephrotic glomeruli. These results indicated that both glycolysic pathway and pentose monophosphate pathway were activated in glomeruli of the rats with Masugi nephritis, and these phenomena may be responsible for the mechanism of repairment in damaged glomeruli.</description><subject>Animals</subject><subject>Disease Models, Animal</subject><subject>Glomerulonephritis - metabolism</subject><subject>Glucose - metabolism</subject><subject>Glycolysis</subject><subject>In Vitro Techniques</subject><subject>Kidney Glomerulus - metabolism</subject><subject>Male</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><issn>0385-2385</issn><issn>1884-0728</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkE9Lw0AQxRdRaqn9CGJO3lL3b3b3KMXWYqsgeg6bZNpu2GRrdoP47U1p8eDlDczvMcx7CN0RPCNccfpQH9q6hcO-845ooWeUz4QmF2hMlOIpllRdojFmSqR0kGs0DcEWmCiJmZB8hEaSyIxIPkaLpetLHyDZQDSFdzY0id8mq-CdiVAlS-cb6Hpnj9t3E0PybeM-2ZjQ72zyevzBRhtu0NXWuADT85ygz8XTx_w5Xb8tV_PHdVoTSnhaiYpnJNMMsGSMqqoAjjXLcCF4hTEWVElVlopvFRYVaIUVNxoMMMmlLAs2Qfenu4fOf_UQYt7YUIJzpgXfh1xhSrUUajDeno190UCVHzrbmO4nPwcf-MuJ1yGaHfxx00VbOsj_NZxTnmcnGYr-c5V70-XQsl8QVHi4</recordid><startdate>198206</startdate><enddate>198206</enddate><creator>Yoneda, Seiichi</creator><creator>Maeda, Masaaki</creator><creator>Yasumi, Masahito</creator><creator>Kimura, Izumi</creator><creator>Nakamura, Kikuo</creator><creator>Minaga, Takeyoshi</creator><creator>Kizu, Akira</creator><creator>Ijichi, Hamao</creator><general>Japanese Society of Nephrology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>198206</creationdate><title>Glucose Metabolism of Isolated Glomeruli of Rats with Masugi Nephritis</title><author>Yoneda, Seiichi ; Maeda, Masaaki ; Yasumi, Masahito ; Kimura, Izumi ; Nakamura, Kikuo ; Minaga, Takeyoshi ; Kizu, Akira ; Ijichi, Hamao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j1214-d5d461693e073328dbe409360b54d00052878cc84f805de98084a9eae37477cb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>jpn</language><creationdate>1982</creationdate><topic>Animals</topic><topic>Disease Models, Animal</topic><topic>Glomerulonephritis - metabolism</topic><topic>Glucose - metabolism</topic><topic>Glycolysis</topic><topic>In Vitro Techniques</topic><topic>Kidney Glomerulus - metabolism</topic><topic>Male</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><toplevel>online_resources</toplevel><creatorcontrib>Yoneda, Seiichi</creatorcontrib><creatorcontrib>Maeda, Masaaki</creatorcontrib><creatorcontrib>Yasumi, Masahito</creatorcontrib><creatorcontrib>Kimura, Izumi</creatorcontrib><creatorcontrib>Nakamura, Kikuo</creatorcontrib><creatorcontrib>Minaga, Takeyoshi</creatorcontrib><creatorcontrib>Kizu, Akira</creatorcontrib><creatorcontrib>Ijichi, Hamao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Nihon Jinzo Gakkai shi</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yoneda, Seiichi</au><au>Maeda, Masaaki</au><au>Yasumi, Masahito</au><au>Kimura, Izumi</au><au>Nakamura, Kikuo</au><au>Minaga, Takeyoshi</au><au>Kizu, Akira</au><au>Ijichi, Hamao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glucose Metabolism of Isolated Glomeruli of Rats with Masugi Nephritis</atitle><jtitle>Nihon Jinzo Gakkai shi</jtitle><addtitle>Jpn J Nephrol</addtitle><date>1982-06</date><risdate>1982</risdate><volume>24</volume><issue>6</issue><spage>591</spage><epage>598</epage><pages>591-598</pages><issn>0385-2385</issn><eissn>1884-0728</eissn><abstract>Renal glomeruli were isolated from the rats 4 days after injection of nephrotoxic serum. 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| ispartof | The Japanese Journal of Nephrology, 1982/06/25, Vol.24(6), pp.591-598 |
| issn | 0385-2385 1884-0728 |
| language | jpn |
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| source | J-STAGE Free; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Disease Models, Animal Glomerulonephritis - metabolism Glucose - metabolism Glycolysis In Vitro Techniques Kidney Glomerulus - metabolism Male Rats Rats, Inbred Strains |
| title | Glucose Metabolism of Isolated Glomeruli of Rats with Masugi Nephritis |
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