Synthesis of new steroid haptens for radioimmunoassay—VII. 19-O-carboxymethyl ether derivative of androstenedione. Specific antiserum for measurement of androstenedione in plasma

Synthesis of new steroid haptens for radioimmunoassay—VII. 19-O-carboxymethyl ether derivative of androstenedione. Specific antiserum for measurement of androstenedione in plasma

The synthesis of 19-O-carboxymethyl ether derivative of androstenedione and the preparation of its bovine serum albumin (BSA) conjugate is described. The BSA conjugate was employed to raise specific antibodies in rabbits suitable for radioimmunoassay (RIA). A non-chromatographic RIA for androstenedi...

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Veröffentlicht in:Journal of steroid biochemistry 1982-11, Vol.17 (5), p.523-527
Hauptverfasser: Rao, Pemmaraju Narasimha, Damodaran, Kalyani M., Moore, Perry H., Desjardoms, Claude, Garza, Romulo
Format: Artikel
Sprache:eng
Schlagworte:
Androstenedione - analogs & derivatives
Androstenedione - blood
Androstenedione - chemical synthesis
Animals
Antibody Specificity
Cross Reactions
Rabbits
Radioimmunoassay - methods
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Zusammenfassung:The synthesis of 19-O-carboxymethyl ether derivative of androstenedione and the preparation of its bovine serum albumin (BSA) conjugate is described. The BSA conjugate was employed to raise specific antibodies in rabbits suitable for radioimmunoassay (RIA). A non-chromatographic RIA for androstenedione is described.
ISSN:0022-4731
DOI:10.1016/0022-4731(82)90011-5