PREPARATION AND CHARACTERIZATION OF DEDESOSAMINYL 5-O-MYCAMINOSYL-10, 11-DIHYDROMYCINAMICIN IV

During the course of search for new antibiotics produced by Micromonospora sp., in addition to the formation of AR-5 (mycinamicin) antibiotics, the authors isolated three neutral components which were characterized from their spectroscopic (PMR, CMR and MS) data. These compounds were named as mycinolide IV, dedesosaminylmycinamicin IV and dedesosaminylmycinamicin V. It was envisioned that a non-antibiotic producing blocked-mutant may be utilized to produce an antibiotic by glycosidation at C-5 of the neutral isolates. The authors now disclose the formation of dedesosaminyl-5-O-mycaminosyl-10,11-dihydromycinamicin IV.