TERRECYCLIC ACID A, A NEW ANTIBIOTIC FROM ASPERGILLUS TERREUS: I. TAXONOMY, PRODUCTION, AND CHEMICAL AND BIOLOGICAL PROPERTIES

A new antibiotic, terrecyclic acid A was isolated from the culture filtrate of a new isolate of fungus, identified as Aspergillus terreus. The fermentation yields reached about one gram per liter of the broth. Chemical and biological characterization of the antibiotic revealed that it was a new sesq...

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Veröffentlicht in:	Journal of antibiotics 1982, Vol.35(7), pp.778-782
Hauptverfasser:	NAKAGAWA, MASAHIRA, HIROTA, AKIRA, SAKAI, HEIICHI, ISOGAI, AKIRA
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - biosynthesis Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Antibiotics, Antineoplastic - isolation & purification Antibiotics, Antineoplastic - metabolism Antibiotics, Antineoplastic - pharmacology Aspergillus - classification Aspergillus - growth & development Aspergillus - metabolism Bacteria - drug effects Drug Resistance, Microbial Fermentation Mice Sesquiterpenes - biosynthesis Sesquiterpenes - isolation & purification Sesquiterpenes - pharmacology
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Beschreibung
Zusammenfassung:	A new antibiotic, terrecyclic acid A was isolated from the culture filtrate of a new isolate of fungus, identified as Aspergillus terreus. The fermentation yields reached about one gram per liter of the broth. Chemical and biological characterization of the antibiotic revealed that it was a new sesquiterpene having a wide antimicrobial spectrum and antitumor activity.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.35.778