Increased DNA Synthetic Potency of Hepatocytes in Cirrhotic Patients May Indicate a Super-High Risk for Hepatocellular Carcinoma

Increased DNA Synthetic Potency of Hepatocytes in Cirrhotic Patients May Indicate a Super-High Risk for Hepatocellular Carcinoma

Bromodeoxyuridine (BrdU) labeling indices (LI) of liver biopsied specimens from 27 control liver cirrhosis patients (control LC) without hepatocellular carcinoma (HCC), 26 cirrhotic patients with HCC, and from 6 control subjects were examined using an in vitro BrdU labeling technique. The mean BrdU...

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Veröffentlicht in:Japanese Journal of Medicine 1990, Vol.29(4), pp.373-378
Hauptverfasser: TARAO, Kazuo, SHIMIZU, Akio, HARADA, Masaoki, OHKAWA, Shinichi, TAMAI, Setsuo, ITO, Yoshihiko, KUNI, Yukifusa, TAKEMIYA, Shoji, OKAMOTO, Takashi
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Blood Chemical Analysis
Bromodeoxyuridine
Carcinoma, Hepatocellular - etiology
Cells, Cultured
DNA - biosynthesis
DNA synthesis
Female
Follow-Up Studies
HCC
Humans
In Vitro Techniques
Liver - metabolism
Liver cirrhosis
Liver Cirrhosis - complications
Liver Cirrhosis - genetics
Liver Neoplasms - etiology
Male
Middle Aged
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Zusammenfassung:Bromodeoxyuridine (BrdU) labeling indices (LI) of liver biopsied specimens from 27 control liver cirrhosis patients (control LC) without hepatocellular carcinoma (HCC), 26 cirrhotic patients with HCC, and from 6 control subjects were examined using an in vitro BrdU labeling technique. The mean BrdU LI±S.E. of HCC cancerous portion, HCC non-cancerous cirrhotic portion, control LC, and control subjects were 6.6±0.8%, 2.7±0.3%, 1.7±0.3% and 0.25±0.09%, respectively. Interestingly, there was a significant difference (p
ISSN:0021-5120
1881-123X
DOI:10.2169/internalmedicine1962.29.373