Double blind comparison of the efficacy of tioconazole and miconazole for the treatment of fungal infection of the skin or erythrasma

Summary A total of ninety‐nine patients, of whom eighty‐six had fungal infections of the skin and thirteen erythrasma, took part in a double blind comparison of the efficacy and acceptability of tioconazole and miconazole creams applied twice daily. The duration of treatment was 4 weeks. Of the patients available for review upon completion of treatment, twenty‐three of thirty‐four patients (68%) treated with tioconazole and twenty‐one of thirty‐eight patients (55%) treated with miconazole were cured clinically and mycologically. Of the patients available for follow‐up 4 weeks later, nineteen of twenty‐one patients (90·5%) treated with tioconazole and twelve of fifteen patients (80%) treated with miconazole remained free from infection. Statistical analysis showed that tioconazole achieved a significantly higher mycological cure rate than miconazole. There was no significant difference between the two creams in clinical or overall cure rates.