α 2-Adrenergic receptors inhibit catecholamine secretion from bovine adrenal medulla

α 2-Adrenergic receptors inhibit catecholamine secretion from bovine adrenal medulla

Catecholamine secretion evoked by carbymlcholine from isolated bovine adrenalinal medullary cells was inhibited byα 2-agonist, clonidine, in a dose-dependent manner with IC 50 value of 2.8 × 10 −5 M. [ 3H]Clonidine bound to adrenal medullary membranes with high affinity and saturable characteristics...

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Veröffentlicht in:Brain research 1982-12, Vol.252 (1), p.189-191
Hauptverfasser: Wada, Akihiko, Sakurai, Seishi, Kobayashi, Hideyuki, Yanagihara, Nobuyuki, Izumi, Futoshi
Format: Artikel
Sprache:eng
Schlagworte:
Adrenal Medulla - innervation
Adrenal Medulla - metabolism
Animals
catecholamine secretion
Catecholamines - metabolism
Cattle
clonidine
Clonidine - metabolism
Clonidine - pharmacology
Culture Techniques
Dose-Response Relationship, Drug
isolated bovine adrenal medullary cells
Receptors, Adrenergic - drug effects
Receptors, Adrenergic, alpha - drug effects
Synaptic Membranes - metabolism
α 2-adrenergic receptor
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Zusammenfassung:Catecholamine secretion evoked by carbymlcholine from isolated bovine adrenalinal medullary cells was inhibited byα 2-agonist, clonidine, in a dose-dependent manner with IC 50 value of 2.8 × 10 −5 M. [ 3H]Clonidine bound to adrenal medullary membranes with high affinity and saturable characteristics. These results suggest thatα 2-adrenergic receptors which exist on adrenal medullary cells have inhibitory effect on the secretion of catecholamine from the cells
ISSN:0006-8993
1872-6240
DOI:10.1016/0006-8993(82)90997-0