Hemorrhage-induced regional brain thyrotropin-releasing hormone release in conscious rats measured by microdialysis

The septum, nucleus accumbens and preoptic area in the brains of conscious, freely moving rats were perfused using microdialysis probes. The TRH concentration significantly increased in the septum after withdrawal of 30% of the total blood volume but remained at constant levels in the other brain ar...

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Veröffentlicht in:	Life sciences (1973) 1990, Vol.47 (22), p.1997-2002
Hauptverfasser:	Okuda, Chieko, Sawa, Teiji, Harada, Masato, Miyazaki, Masao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - drug effects Brain - metabolism Dialysis Hemorrhage - physiopathology Male Nucleus Accumbens - metabolism Potassium - pharmacology Preoptic Area - drug effects Preoptic Area - metabolism Rats Rats, Inbred Strains Septum Pellucidum - drug effects Septum Pellucidum - metabolism Thyrotropin-Releasing Hormone - metabolism
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Zusammenfassung:	The septum, nucleus accumbens and preoptic area in the brains of conscious, freely moving rats were perfused using microdialysis probes. The TRH concentration significantly increased in the septum after withdrawal of 30% of the total blood volume but remained at constant levels in the other brain areas. Also, high potassium dose-dependently stimulated TRH release in vivo. These results suggest that blood loss stimulates septal TRH release, probably by membrane depolarization of TRH-containing nerve terminals.
ISSN:	0024-3205 1879-0631
DOI:	10.1016/0024-3205(90)90433-R