MM 46115, A NEW ANTIVIRAL ANTIBIOTIC FROM ACTINOMADURA PELLETIERI: CHARACTERISTICS OF THE PRODUCING CULTURES, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES
Six strains of Actinomadura pelletieri were shown to produce a novel macrolide antibiotic, designated MM 46115. MM 46115 was active against parainfluenza virus 1 and 2 and Grampositive bacteria. Methods are described for the production of MM 46115 by strain IP 729.63, and for the isolation of the co...
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| Veröffentlicht in: | Journal of antibiotics 1990/11/25, Vol.43(11), pp.1387-1393 |
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| container_end_page | 1393 |
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| container_issue | 11 |
| container_start_page | 1387 |
| container_title | Journal of antibiotics |
| container_volume | 43 |
| creator | ASHTON, RAYMOND J. KENIG, MARTIN D. LUK, KONG PLANTEROSE, DONALD N. SCOTT-WOOD, GILLIAN |
| description | Six strains of Actinomadura pelletieri were shown to produce a novel macrolide antibiotic, designated MM 46115. MM 46115 was active against parainfluenza virus 1 and 2 and Grampositive bacteria. Methods are described for the production of MM 46115 by strain IP 729.63, and for the isolation of the compound from a butanol extract of the culture filtrate. |
| doi_str_mv | 10.7164/antibiotics.43.1387 |
| format | Article |
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MM 46115 was active against parainfluenza virus 1 and 2 and Grampositive bacteria. Methods are described for the production of MM 46115 by strain IP 729.63, and for the isolation of the compound from a butanol extract of the culture filtrate.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.7164/antibiotics.43.1387</identifier><identifier>PMID: 2177052</identifier><identifier>CODEN: JANTAJ</identifier><language>eng</language><publisher>Tokyo: JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</publisher><subject>Animals ; Anti-Bacterial Agents - biosynthesis ; Anti-Bacterial Agents - chemical synthesis ; Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - isolation & purification ; Anti-Bacterial Agents - pharmacology ; Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents ; Antiviral Agents - chemistry ; Antiviral Agents - isolation & purification ; Antiviral Agents - pharmacology ; Applied microbiology ; Biological and medical sciences ; Chemotherapic agents ; Fermentation ; Fundamental and applied biological sciences. Psychology ; Gram-Positive Bacteria - drug effects ; Humans ; Influenza A virus - drug effects ; Leukemia L1210 - drug therapy ; Macrolides ; Microbiology ; Mitosporic Fungi - drug effects ; Molecular Structure ; Nocardiaceae - metabolism ; Respiratory Syncytial Viruses - drug effects ; Respirovirus - drug effects ; Trichophyton - drug effects ; Tumor Cells, Cultured</subject><ispartof>The Journal of Antibiotics, 1990/11/25, Vol.43(11), pp.1387-1393</ispartof><rights>Japan Antibiotics Research Association</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4277-10f6b036a8f62053e11e38766daacce2104f99c268d3d7b45ab007c6daa1e1213</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19536480$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2177052$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ASHTON, RAYMOND J.</creatorcontrib><creatorcontrib>KENIG, MARTIN D.</creatorcontrib><creatorcontrib>LUK, KONG</creatorcontrib><creatorcontrib>PLANTEROSE, DONALD N.</creatorcontrib><creatorcontrib>SCOTT-WOOD, GILLIAN</creatorcontrib><title>MM 46115, A NEW ANTIVIRAL ANTIBIOTIC FROM ACTINOMADURA PELLETIERI: CHARACTERISTICS OF THE PRODUCING CULTURES, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES</title><title>Journal of antibiotics</title><addtitle>J. Antibiot.</addtitle><description>Six strains of Actinomadura pelletieri were shown to produce a novel macrolide antibiotic, designated MM 46115. MM 46115 was active against parainfluenza virus 1 and 2 and Grampositive bacteria. Methods are described for the production of MM 46115 by strain IP 729.63, and for the isolation of the compound from a butanol extract of the culture filtrate.</description><subject>Animals</subject><subject>Anti-Bacterial Agents - biosynthesis</subject><subject>Anti-Bacterial Agents - chemical synthesis</subject><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - isolation & purification</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents</subject><subject>Antiviral Agents - chemistry</subject><subject>Antiviral Agents - isolation & purification</subject><subject>Antiviral Agents - pharmacology</subject><subject>Applied microbiology</subject><subject>Biological and medical sciences</subject><subject>Chemotherapic agents</subject><subject>Fermentation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gram-Positive Bacteria - drug effects</subject><subject>Humans</subject><subject>Influenza A virus - drug effects</subject><subject>Leukemia L1210 - drug therapy</subject><subject>Macrolides</subject><subject>Microbiology</subject><subject>Mitosporic Fungi - drug effects</subject><subject>Molecular Structure</subject><subject>Nocardiaceae - metabolism</subject><subject>Respiratory Syncytial Viruses - drug effects</subject><subject>Respirovirus - drug effects</subject><subject>Trichophyton - drug effects</subject><subject>Tumor Cells, Cultured</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkM1OwzAQhC0EglJ4AoSUC5xI8dqO7RxDSSFS2qIqwNFyXAeC0h_i9MDbk7ZR4WJbmm9n1oPQFeCBAM7u9bIp83LVlMYNGB0AleII9UBK8IHx8Bj1MCbgS0nwGTp37gtjKqiQp-iUgBA4ID0Ujcce4wDBnRd5k_jdiyZZ8pbMonT3ekimWTL0RrPp2IuGWTKZjqPH11nkvcRpGmdJPEsu0EmhK2cvu7uPXkdxNnz20-lTMoxS3zAihA-44DmmXMuCExxQC2DbhTmfa22MJYBZEYaGcDmnc5GzQOcYC7OVwQIB2ke3e991vfreWNeoRemMrSq9tKuNU7L9K-E0bEG6B029cq62hVrX5ULXPwqw2han_hWnGFXb4tqp685-ky_s_DDTNdXqN52undFVUeulKd2fdRhQziRuucme-3KN_rAHQNdtXGX_Z0PI5S4funO7yAE0n7pWdkl_AXnzjaQ</recordid><startdate>1990</startdate><enddate>1990</enddate><creator>ASHTON, RAYMOND J.</creator><creator>KENIG, MARTIN D.</creator><creator>LUK, KONG</creator><creator>PLANTEROSE, DONALD N.</creator><creator>SCOTT-WOOD, GILLIAN</creator><general>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</general><general>Japan Antibiotics Research Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1990</creationdate><title>MM 46115, A NEW ANTIVIRAL ANTIBIOTIC FROM ACTINOMADURA PELLETIERI</title><author>ASHTON, RAYMOND J. ; KENIG, MARTIN D. ; LUK, KONG ; PLANTEROSE, DONALD N. ; SCOTT-WOOD, GILLIAN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4277-10f6b036a8f62053e11e38766daacce2104f99c268d3d7b45ab007c6daa1e1213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Animals</topic><topic>Anti-Bacterial Agents - biosynthesis</topic><topic>Anti-Bacterial Agents - chemical synthesis</topic><topic>Anti-Bacterial Agents - chemistry</topic><topic>Anti-Bacterial Agents - isolation & purification</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents</topic><topic>Antiviral Agents - chemistry</topic><topic>Antiviral Agents - isolation & purification</topic><topic>Antiviral Agents - pharmacology</topic><topic>Applied microbiology</topic><topic>Biological and medical sciences</topic><topic>Chemotherapic agents</topic><topic>Fermentation</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gram-Positive Bacteria - drug effects</topic><topic>Humans</topic><topic>Influenza A virus - drug effects</topic><topic>Leukemia L1210 - drug therapy</topic><topic>Macrolides</topic><topic>Microbiology</topic><topic>Mitosporic Fungi - drug effects</topic><topic>Molecular Structure</topic><topic>Nocardiaceae - metabolism</topic><topic>Respiratory Syncytial Viruses - drug effects</topic><topic>Respirovirus - drug effects</topic><topic>Trichophyton - drug effects</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ASHTON, RAYMOND J.</creatorcontrib><creatorcontrib>KENIG, MARTIN D.</creatorcontrib><creatorcontrib>LUK, KONG</creatorcontrib><creatorcontrib>PLANTEROSE, DONALD N.</creatorcontrib><creatorcontrib>SCOTT-WOOD, GILLIAN</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ASHTON, RAYMOND J.</au><au>KENIG, MARTIN D.</au><au>LUK, KONG</au><au>PLANTEROSE, DONALD N.</au><au>SCOTT-WOOD, GILLIAN</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MM 46115, A NEW ANTIVIRAL ANTIBIOTIC FROM ACTINOMADURA PELLETIERI: CHARACTERISTICS OF THE PRODUCING CULTURES, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES</atitle><jtitle>Journal of antibiotics</jtitle><addtitle>J. Antibiot.</addtitle><date>1990</date><risdate>1990</risdate><volume>43</volume><issue>11</issue><spage>1387</spage><epage>1393</epage><pages>1387-1393</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><coden>JANTAJ</coden><abstract>Six strains of Actinomadura pelletieri were shown to produce a novel macrolide antibiotic, designated MM 46115. MM 46115 was active against parainfluenza virus 1 and 2 and Grampositive bacteria. Methods are described for the production of MM 46115 by strain IP 729.63, and for the isolation of the compound from a butanol extract of the culture filtrate.</abstract><cop>Tokyo</cop><pub>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</pub><pmid>2177052</pmid><doi>10.7164/antibiotics.43.1387</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-8820 |
| ispartof | The Journal of Antibiotics, 1990/11/25, Vol.43(11), pp.1387-1393 |
| issn | 0021-8820 1881-1469 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80212639 |
| source | J-STAGE Free; MEDLINE |
| subjects | Animals Anti-Bacterial Agents - biosynthesis Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Antiviral Agents - chemistry Antiviral Agents - isolation & purification Antiviral Agents - pharmacology Applied microbiology Biological and medical sciences Chemotherapic agents Fermentation Fundamental and applied biological sciences. Psychology Gram-Positive Bacteria - drug effects Humans Influenza A virus - drug effects Leukemia L1210 - drug therapy Macrolides Microbiology Mitosporic Fungi - drug effects Molecular Structure Nocardiaceae - metabolism Respiratory Syncytial Viruses - drug effects Respirovirus - drug effects Trichophyton - drug effects Tumor Cells, Cultured |
| title | MM 46115, A NEW ANTIVIRAL ANTIBIOTIC FROM ACTINOMADURA PELLETIERI: CHARACTERISTICS OF THE PRODUCING CULTURES, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES |
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