MM 46115, A NEW ANTIVIRAL ANTIBIOTIC FROM ACTINOMADURA PELLETIERI: CHARACTERISTICS OF THE PRODUCING CULTURES, FERMENTATION, ISOLATION, PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES

Six strains of Actinomadura pelletieri were shown to produce a novel macrolide antibiotic, designated MM 46115. MM 46115 was active against parainfluenza virus 1 and 2 and Grampositive bacteria. Methods are described for the production of MM 46115 by strain IP 729.63, and for the isolation of the co...

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Veröffentlicht in:	Journal of antibiotics 1990/11/25, Vol.43(11), pp.1387-1393
Hauptverfasser:	ASHTON, RAYMOND J., KENIG, MARTIN D., LUK, KONG, PLANTEROSE, DONALD N., SCOTT-WOOD, GILLIAN
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - biosynthesis Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Antiviral Agents - chemistry Antiviral Agents - isolation & purification Antiviral Agents - pharmacology Applied microbiology Biological and medical sciences Chemotherapic agents Fermentation Fundamental and applied biological sciences. Psychology Gram-Positive Bacteria - drug effects Humans Influenza A virus - drug effects Leukemia L1210 - drug therapy Macrolides Microbiology Mitosporic Fungi - drug effects Molecular Structure Nocardiaceae - metabolism Respiratory Syncytial Viruses - drug effects Respirovirus - drug effects Trichophyton - drug effects Tumor Cells, Cultured
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Zusammenfassung:	Six strains of Actinomadura pelletieri were shown to produce a novel macrolide antibiotic, designated MM 46115. MM 46115 was active against parainfluenza virus 1 and 2 and Grampositive bacteria. Methods are described for the production of MM 46115 by strain IP 729.63, and for the isolation of the compound from a butanol extract of the culture filtrate.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.43.1387