Activation of plasminogen by tissue activator is increased specifically in the presence of certain soluble fibrin(ogen) fragments

Tissue activator-mediated plasminogen activation is potentiated both by fibrin and by some soluble fibrin(ogen) fragments. The potentiating effect of the different fragments decreases in the order fibrin monomer > D-dimer > Y > D EGTA > Dcate > X. Fibrinogen and the fragments Ecate, E...

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Veröffentlicht in:	Thrombosis research 1982-08, Vol.27 (4), p.377-385
Hauptverfasser:	Verheijen, J.H., Nieuwenhuizen, W., Wijngaards, G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Fibrin - pharmacology Fibrin Fibrinogen Degradation Products - pharmacology fibrin(ogen) fragments Fibrinogen - pharmacology Humans Plasminogen - metabolism plasminogen activation Plasminogen Activators - pharmacology Thromboplastin - pharmacology Tissue plasminogen activator urokinase Urokinase-Type Plasminogen Activator - pharmacology
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Zusammenfassung:	Tissue activator-mediated plasminogen activation is potentiated both by fibrin and by some soluble fibrin(ogen) fragments. The potentiating effect of the different fragments decreases in the order fibrin monomer > D-dimer > Y > D EGTA > Dcate > X. Fibrinogen and the fragments Ecate, E EGTA and E fibrin have almost no effect. The existence of a fibrin polymer is apparently not a prerequisite for this potentiating effect. The plasminogen activation by various urokinase preparations is not potentiated by fibrin and fibrin(ogen) fragments.
ISSN:	0049-3848 1879-2472
DOI:	10.1016/0049-3848(82)90055-X