A recombination map of the human X-chromosome

A recombination map of the human X-chromosome

A family with 11 normal boys has been typed with DNA probes spanning the whole of the X-chromosome to observe directly the recombination events in 11 meioses from one female. This has (a) identified apparent recombination hot-spots on the X-chromosome; (b) shown the positions and numbers of cross-ov...

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Veröffentlicht in:Human genetics 1990-12, Vol.86 (2), p.228-230
Hauptverfasser: DEL MASTRO, R. G, FARNDON, P. A, KILPATRICK, M. W
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Chromosome Banding
Chromosome Mapping
DNA Probes
Female
Fundamental and applied biological sciences. Psychology
Humans
Male
Molecular and cellular biology
Recombination, Genetic
X Chromosome
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Zusammenfassung:A family with 11 normal boys has been typed with DNA probes spanning the whole of the X-chromosome to observe directly the recombination events in 11 meioses from one female. This has (a) identified apparent recombination hot-spots on the X-chromosome; (b) shown the positions and numbers of cross-overs that have occurred in the p and q arms; (c) not shown any cross-overs in the centromeric region and (d) enabled the calculation of the genetic length of the X-chromosome.
ISSN:0340-6717
1432-1203
DOI:10.1007/BF00197710