Oocyte donation: the role of endometrial receptivity

Sixteen patients, 15 with primary ovarian failure and one carrier of chromosomal abnormality, received 21 embryo transfers following in-vitro fertilization of donated oocytes. Hormone replacement therapy was given to mimic a natural menstrual cycle. Five pregnancies were achieved (four infants deliv...

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Veröffentlicht in:Human reproduction (Oxford) 1990-10, Vol.5 (7), p.862-869
Hauptverfasser: Davies, M.C., Anderson, M.C., Mason, B.A., Jacobs, H.S.
Format: Artikel
Sprache:eng
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Zusammenfassung:Sixteen patients, 15 with primary ovarian failure and one carrier of chromosomal abnormality, received 21 embryo transfers following in-vitro fertilization of donated oocytes. Hormone replacement therapy was given to mimic a natural menstrual cycle. Five pregnancies were achieved (four infants delivered and one early pregnancy loss). All patients had endometrial biopsies taken in a preceding cycle of hormone replacement therapy. The majority (61%) showed delayed maturation compared with the expected appearances for the day of the cycle as assessed on light microscopy. Patients who conceived had a significantly better endometrial respome than those who did not. Five out of seven patients (71%) conceived when the endometrium was ‘in phase’ (
ISSN:0268-1161
1460-2350
DOI:10.1093/oxfordjournals.humrep.a137199