Oocyte donation: the role of endometrial receptivity
Sixteen patients, 15 with primary ovarian failure and one carrier of chromosomal abnormality, received 21 embryo transfers following in-vitro fertilization of donated oocytes. Hormone replacement therapy was given to mimic a natural menstrual cycle. Five pregnancies were achieved (four infants deliv...
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Veröffentlicht in: | Human reproduction (Oxford) 1990-10, Vol.5 (7), p.862-869 |
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Hauptverfasser: | , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Sixteen patients, 15 with primary ovarian failure and one carrier of chromosomal abnormality, received 21 embryo transfers following in-vitro fertilization of donated oocytes. Hormone replacement therapy was given to mimic a natural menstrual cycle. Five pregnancies were achieved (four infants delivered and one early pregnancy loss). All patients had endometrial biopsies taken in a preceding cycle of hormone replacement therapy. The majority (61%) showed delayed maturation compared with the expected appearances for the day of the cycle as assessed on light microscopy. Patients who conceived had a significantly better endometrial respome than those who did not. Five out of seven patients (71%) conceived when the endometrium was ‘in phase’ ( |
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ISSN: | 0268-1161 1460-2350 |
DOI: | 10.1093/oxfordjournals.humrep.a137199 |